PMID: 3756769Nov 15, 1986Paper

Estramustine affects bone mineral metabolism in metastatic prostate cancer

Cancer
D L CitrinW Hauck

Abstract

A patient with metastatic prostate cancer is described where treatment with Adriamycin (doxorubicin) and estramustine produced severe hypophosphatemia (serum phosphate level, 1.2 mg/dl), which was reversible when treatment was discontinued. Previous studies have shown no effect of Adriamycin on serum phosphate levels. A retrospective study of serial serum chemistry values was done in 15 patients treated with estramustine. A significant fall in the serum phosphate level (mean, 0.8 +/- 0.3 mg/dl) was observed during the first 6 weeks of treatment. When compared with similar patients treated with bilateral orchiectomy, estramustine-treated patients had lower levels of serum calcium, fractional excretion of calcium, serum phosphate, and renal tubular threshold for phosphate reabsorption (TmPO4/GFR). Qualitatively similar but quantitatively smaller effects were also seen in a group of patients treated with diethylstilbestrol (DES) in a dose of 1 to 3 mg daily. Estramustine appears to have significant effects on bone mineral metabolism, particularly on renal phosphate handling resulting in significant hypophosphatemia. This is probably due to an estrogenic effect.

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Citations

Jan 1, 1988·Pharmacology & Therapeutics·A A Sandberg, R Y Kirdani
Apr 2, 2010·QJM : Monthly Journal of the Association of Physicians·G LiamisM Elisaf
May 5, 2009·Journal of Cancer Survivorship : Research and Practice·Charles J StavaRena Vassilopoulou-Sellin
Mar 5, 2016·European Journal of Pharmacology·George LiamisMoses S Elisaf
May 30, 2002·The American Journal of Medicine·Dana L MadisonMichael M Bliziotes
Aug 28, 2003·International Journal of Urology : Official Journal of the Japanese Urological Association·Hidetoshio KurumaShiro Baba
Apr 4, 2017·The International Journal of Eating Disorders·L BeatyP Mehler

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