Estranediols profiling in calves' urine after 17beta-nandrolone laureate ester administration

The Journal of Steroid Biochemistry and Molecular Biology
Gaud PinelBruno Le Bizec

Abstract

17beta-Nandrolone (17beta-NT) is one of the most recurrent forbidden anabolic steroid used in meat producing animals breeding. Because efficient control must both take into account metabolic patterns and associated kinetics of elimination, the metabolism of 17beta-NT in bovines has already been investigated and is well documented, but only focussing on its main metabolites (i.e. 17alpha-nandrolone, 19-noretiocholanolone and 19-norandrostenedione). The goal of the present study was to enlarge this panel of 17beta-NT metabolites, especially through the urinary estranediols fraction in order to perform a more global steroid profiling upon 17beta-nortestosterone laureate ester administration in calves. A GC-MS/MS method has been developed to monitor and quantify 5 estranediols isomers including 5alpha-estrane-3beta,17beta-diol (abb), 5beta-estrane-3alpha,17beta-diol (bab), 5alpha-estrane-3beta,17alpha-diol (aba), 5alpha-estrane-3alpha,17beta-diol (aab) and 5beta-estrane-3alpha,17alpha-diol (baa). Their urinary elimination kinetics have been established allowing detection of 4 estranediols up to several days after administration. All animals demonstrated homogeneous patterns of elimination both from a qualitative (metabolite profile...Continue Reading

References

Nov 1, 1977·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·E Houghton
Apr 5, 1991·Journal of Chromatography·M VandenbroeckG Maghuin-Rogister
May 1, 1980·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·E Houghton, M C Dumasia
Dec 1, 1994·The Analyst·H F de BrabanderR W Stephany
Feb 17, 1999·The Veterinary Quarterly·J D McEvoyB M McCartan
Mar 18, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·B Le BizecF André
Dec 18, 2001·Rapid Communications in Mass Spectrometry : RCM·S ImpensH De Brabander
May 15, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Christof Van Poucke, Carlos Van Peteghem
Jul 12, 2002·Rapid Communications in Mass Spectrometry : RCM·Don H CatlinYulia Kucherova
Sep 30, 2005·Food Additives and Contaminants·S PoelmansH F De Brabander
Nov 23, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Michel W F NielenMaria J Groot
Mar 22, 2008·The Journal of Steroid Biochemistry and Molecular Biology·Gaud PinelBruno Le Bizec
Aug 15, 2009·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·J ScarthJ Kay

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Citations

Jun 2, 2012·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·M H BloklandM W F Nielen
May 31, 2011·The Journal of Steroid Biochemistry and Molecular Biology·Gaud Dervilly-PinelBruno Le Bizec
Aug 8, 2012·Drug Testing and Analysis·Gaud Dervilly-PinelBruno Le Bizec
Jan 7, 2015·Bioanalysis·Hector Gallart-AyalaBruno Le Bizec
Mar 13, 2018·Analytical Chemistry·Maykel Hernández-MesaGaud Dervilly-Pinel

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