Estriol-mediated neuroprotection in multiple sclerosis localized by voxel-based morphometry

Brain and Behavior
Allan MacKenzie-GrahamRhonda R Voskuhl

Abstract

Progressive gray matter (GM) atrophy is a hallmark of multiple sclerosis (MS). Cognitive impairment has been observed in 40%-70% of MS patients and has been linked to GM atrophy. In a phase 2 trial of estriol treatment in women with relapsing-remitting MS (RRMS), higher estriol levels correlated with greater improvement on the paced auditory serial addition test (PASAT) and imaging revealed sparing of localized GM in estriol-treated compared to placebo-treated patients. To better understand the significance of this GM sparing, the current study explored the relationships between the GM sparing and traditional MRI measures and clinical outcomes. Sixty-two estriol- and forty-nine placebo-treated RRMS patients underwent clinical evaluations and brain MRI. Voxel-based morphometry (VBM) was used to evaluate voxelwise GM sparing from high-resolution T1-weighted scans. A region of treatment-induced sparing (TIS) was defined as the areas where GM was spared in estriol- as compared to placebo-treated groups, localized primarily within the frontal and parietal cortices. We observed that TIS volume was directly correlated with improvement on the PASAT. Next, a longitudinal cognitive disability-specific atlas (DSA) was defined by correlati...Continue Reading

Associated Clinical Trials

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Citations

Jan 23, 2020·Multiple Sclerosis : Clinical and Laboratory Research·Rhonda R Voskuhl
Aug 30, 2020·Biology of Sex Differences·Rhonda R VoskuhlAllan MacKenzie-Graham
Jul 31, 2018·Multiple Sclerosis : Clinical and Laboratory Research·Rhonda Voskuhl
Jul 14, 2020·Therapeutic Advances in Neurological Disorders·Kristen M KryskoKerstin Hellwig
Sep 9, 2020·Multiple Sclerosis and Related Disorders·Ali MotavalliSaeed Sadigh-Eteghad
Jan 8, 2021·Brain Communications·Burcu ZeydanOrhun H Kantarci

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Clinical Trials Mentioned

NCT00451204
NCT01466114

Software Mentioned

gplots
SPM8
SAS
DARTEL
VBM8
Statistical Parametric Mapping 8 ( SPM8
DARTEL )
STST
R

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