Estrogen- and Satiety State-Dependent Metabolic Lateralization in the Hypothalamus of Female Rats

PloS One
Istvan TothAttila Zsarnovszky

Abstract

Hypothalamus is the highest center and the main crossroad of numerous homeostatic regulatory pathways including reproduction and energy metabolism. Previous reports indicate that some of these functions may be driven by the synchronized but distinct functioning of the left and right hypothalamic sides. However, the nature of interplay between the hemispheres with regard to distinct hypothalamic functions is still unclear. Here we investigated the metabolic asymmetry between the left and right hypothalamic sides of ovariectomized female rats by measuring mitochondrial respiration rates, a parameter that reflects the intensity of cell and tissue metabolism. Ovariectomized (saline injected) and ovariectomized+estrogen injected animals were fed ad libitum or fasted to determine 1) the contribution of estrogen to metabolic asymmetry of hypothalamus; and 2) whether the hypothalamic asymmetry is modulated by the satiety state. Results show that estrogen-priming significantly increased both the proportion of animals with detected hypothalamic lateralization and the degree of metabolic difference between the hypothalamic sides causing a right-sided dominance during state 3 mitochondrial respiration (St3) in ad libitum fed animals. After...Continue Reading

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Citations

Sep 20, 2018·Acta Psychiatrica Scandinavica·S SchindlerP Schönknecht
Feb 13, 2020·Reproductive Sciences·David S KissAttila Zsarnovszky
Jun 25, 2020·Brain Sciences·David Sandor KissAttila Zsarnovszky
Oct 22, 2020·Pediatric Obesity·Leticia E SewaybrickerEllen A Schur

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