Estrogen absorption and metabolism in postmenopausal women with end-stage renal disease

The Journal of Clinical Endocrinology and Metabolism
E S GinsburgB W Walsh

Abstract

Women with end-stage renal disease (ESRD) have a higher rate of death from heart disease than women with normal renal function. Because estrogen replacement therapy may significantly decrease the incidence of death due to cardiovascular disease in postmenopausal women with normal renal function, their use has been considered for women with ESRD. However, the pharmacokinetics of estrogen have not been studied in postmenopausal women with ESRD to determine the optimal estrogen dose. Six postmenopausal women with ESRD receiving maintenance hemodialysis and six controls matched for body mass index were admitted to the in-patient Clinical Research Center. A 1- or 2-mg oral estradiol (E2) pill was given while subjects fasted. Blood sampling was performed over the next 24 h for measurement of E2, estrone (E1), albumin, and sex hormone-binding globulin (SHBG). Three weeks later, the subjects were given the other E2 dose under identical conditions. At baseline, total and free E2 levels were higher in the subjects with ESRD than in controls (P = 0.0005 and 0.0035, respectively). After ingestion of 1 and 2 mg E2, total and free E2 levels remained significantly higher in the ESRD subjects from 2-8 h after treatment (P < or = 0.05). After 1...Continue Reading

Citations

May 31, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Holly Mattix KramerUNKNOWN HELP Study Group
Oct 20, 2004·Advances in Chronic Kidney Disease·Gail D Anderson, Peggy S Odegard
Jul 8, 2000·Kidney International·J R WeisingerE Bellorín-Font
May 20, 2003·Kidney International. Supplement·A Rodríguez-RodríguezJ B Cannata-Andía
May 20, 2003·Kidney International. Supplement·José R WeisingerEzequiel Bellorin-Font

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