Estrogen actions in the male reproductive system involve estrogen response element-independent pathways.

Endocrinology
Jeffrey WeissJ Larry Jameson

Abstract

The estrogen receptor-alpha (ERalpha) acts through multiple pathways, including estrogen response element (ERE)-dependent (classical) and ERE-independent (nonclassical) mechanisms. We previously created a mouse model harboring a two-amino-acid mutation of the DNA-binding domain (E207A, G208A) that precludes direct binding of ERalpha to an ERE. After crossing heterozygous mutant mice with an ERalpha knockout (ERKO) line, it was possible to assess the degree of physiological rescue by the isolated ERalpha nonclassical allele (-/AA; AA) when compared with ERKO mice (-/-) and to wild type (+/+; WT). In male ERKO mice up to 8 months of age, testosterone levels were high, although LH levels were similar to WT. Testosterone was normal in the AA mice, indicating that the AA allele rescues the enhanced testosterone biosynthesis in ERKO mice. Male ERKO mice exhibited distention of the seminiferous tubules as early as 2-3 months of age as a consequence of decreased water resorption in the efferent ducts. By 3-4 months of age, ERKO mice had impaired spermatogenesis in approximately 40% of their tubules, and sperm counts and motility declined in association with the histological changes. In the AA mice, histological defects were greatly red...Continue Reading

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Citations

Dec 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Yukitomo AraoKenneth S Korach
Oct 12, 2010·Biology of Reproduction·Avenel JosephRex A Hess
Apr 21, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Serge Carreau, Rex A Hess
Sep 14, 2010·The Journal of Endocrinology·Eugenia H GouldingEdward M Eddy
Nov 12, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Mohammad Shah AlamMasamichi Kurohmaru
Apr 12, 2011·Current Opinion in Endocrinology, Diabetes, and Obesity·Stephanie T Page
Feb 14, 2018·Biology of Reproduction·Rex A Hess, Paul S Cooke
May 26, 2017·Physiological Reviews·Paul S CookeRex A Hess
Oct 21, 2017·Reproduction in Domestic Animals = Zuchthygiene·M YesteN Prieto-Martínez
Jan 15, 2021·Differentiation; Research in Biological Diversity·Rex A HessBarry T Hinton
Mar 22, 2021·Animal Reproduction Science·Nicola MirabellaCaterina Squillacioti
Jun 3, 2021·International Journal of Molecular Sciences·Agata Wawrzkiewicz-JałowieckaGraça Soveral
Jul 25, 2021·Animal Reproduction Science·Patrycja Oberska, Katarzyna Michałek

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