PMID: 8592137Feb 1, 1996Paper

Estrogen alters MPTP-induced neurotoxicity in female mice: effects on striatal dopamine concentrations and release

Journal of Neurochemistry
D E DluzenB Liu

Abstract

The effects of estrogen on MPTP-induced neurotoxicity of the nigrostriatal dopaminergic system were examined in C57Bl and CD-1 mice. Ovariectomized mice with and without estrogen were treated with MPTP or its vehicle. The effects of these treatments on striatal dopamine concentrations and L-DOPA-stimulated dopamine and L-3,4-dihydroxyphenylacetic acid (DOPAC) release in vitro were determined. Dopamine concentrations of C57Bl mice receiving estrogen before MPTP were significantly greater than those of non-estrogen-treated MPTP mice as well as estrogen-treated mice receiving the MPTP vehicle. Dopamine concentrations of the CD-1 mice did not differ with these treatments. L-DOPA-evoked dopamine release values of estrogen-treated C57Bl mice were significantly increased compared with non-estrogen-treated mice. No such differences were observed in the MPTP-treated C57Bl mice. DOPAC release rates were similar to that of dopamine in these C57Bl mice. In the CD-1 mice estrogen also produced a significant increase in L-DOPA-evoked dopamine release; however, this response was unaltered by MPTP treatment. A significant increase in L-DOPA-evoked DOPAC output was obtained only for estrogen-treated CD-1 mice. Both strains show very similar res...Continue Reading

Citations

Nov 21, 2000·Annals of the New York Academy of Sciences·D E Dluzen, J L McDermott
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