Estrogen and alendronate therapies may prevent the influence of estrogen deficiency on the tooth-supporting alveolar bone: a histometric study in rats

Journal of Periodontal Research
Poliana Mendes DuarteFrancisco H Nociti

Abstract

The aim of this study was to evaluate histometrically the influence of estrogen deficiency, and its therapies, on the quality of the tooth-supporting alveolar bone. Seventy-three female rats were randomly assigned to one of the following groups: group 1 (n = 15), sham surgery; group 2 (n = 15), bilateral ovariectomy (OVX); group 3 (n = 14), OVX plus calcitonin (16 IU/kg); group 4 (n = 14), OVX plus estrogen (20 microg/kg); and group 5 (n = 15), OVX plus alendronate (5 mg/kg). Eighty days after surgery, the animals were killed and their mandibles were removed and processed for histology. Bone density (BD) in the furcation area of the first mandibular molar (i.e. the percentage of demineralized bone tissue in a 1,000 microm zone under the furcation) was histometrically obtained. Data analysis demonstrated that estrogen deficiency negatively affected the tooth-supporting bone density (79.45% +/- 4.22 and 55.23% +/- 6.45, for groups 1 and 2, respectively), and that estradiol and alendronate therapies prevented this effect (61.67% +/- 6.87, 78.09% +/- 3.12 and 81.47% +/- 4.58, for groups 3, 4 and 5, respectively). Within the limits of this study, it can be concluded that the density of tooth-supporting bone is affected by estrogen d...Continue Reading

References

Apr 1, 1992·Calcified Tissue International·R Pacifici
Oct 1, 1991·Endocrinology·T J WronskiP P DeLuca
Feb 1, 1990·The Journal of Prosthetic Dentistry·P J Kribbs
Feb 1, 1986·Calcified Tissue International·D GonzálezC Mautalen
Mar 1, 1987·Calcified Tissue International·T J WronskiC C Walsh
Sep 1, 1972·The Journal of Clinical Investigation·F R SingerK J Bloch
Jun 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·H H Messer, D H Copp
Apr 1, 1984·Metabolism: Clinical and Experimental·H E GruberC H Chesnut
Nov 27, 1995·Archives of Internal Medicine·A Paganini-Hill
Dec 1, 1994·Journal of Periodontology·N von WowernG Kollerup
Mar 1, 1994·Journal of Clinical Periodontology·E KlemettiV Lassila
Apr 1, 1996·Calcified Tissue International·Y ShenT J Wronski
Oct 6, 1997·Journal of Periodontology·R B JohnsonC F Streckfus
May 23, 1998·Annual Review of Pharmacology and Toxicology·G A Rodan
Sep 1, 2000·Science·G A Rodan, T J Martin
Jul 11, 2001·Journal of Women's Health & Gender-based Medicine·M M ReganS L Greenspan
Mar 13, 2002·Annals of Periodontology·C H Chesnut
May 15, 2002·Journal of Periodontal Research·M TanakaH Ozawa
Nov 12, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Robert S WeinsteinDouglas B Muchmore
Jan 3, 2004·Yonsei Medical Journal·Semih AkiUNKNOWN Turkish Osteoporosis Society
Mar 11, 2004·Journal of Periodontal Research·Poliana Mendes DuarteFrancisco Humberto Nociti
Nov 2, 2004·Journal of Periodontology·Poliana Mendes DuarteFrancisco H Nociti
Apr 27, 2005·Joint, Bone, Spine : Revue Du Rhumatisme·François BodicDaniel Chappard
Jan 18, 2006·The American Journal of Medicine·Andrea Z LaCroix
Feb 4, 2006·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Torsten HansenC James Kirkpatrick
Mar 4, 2006·Journal of the American Board of Family Medicine : JABFM·Mary Ann BurgUNKNOWN Florida Behavioral Health Research Consortium

❮ Previous
Next ❯

Citations

Jan 5, 2011·International Journal of Evidence-based Healthcare·Emma MegsonP Mark Bartold
Jun 12, 2012·Journal of Periodontology·Valdir Gouveia GarciaLetícia Helena Theodoro
Aug 10, 2012·Journal of Periodontology·Joyce Pinho BezerraMarta Ferreira Bastos
Aug 24, 2010·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Giscard José Ribeiro MachadoRita Cássia Menegati Dornelles
Sep 11, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Edwin R CadetChristopher S Ahmad
Sep 29, 2015·Clinical Oral Investigations·Rafael Scaf de MolonJoni Augusto Cirelli
Jun 11, 2015·BioMed Research International·Bryan D Johnston, Wendy E Ward
Apr 9, 2008·The Journal of Oral Implantology·Jamil Awad ShibliAdriano Piattelli
May 16, 2008·The Journal of Oral Implantology·Yeritxa E Viera-NegrónJames L Borke
Jan 16, 2015·Journal of Applied Oral Science : Revista FOB·Tábata de Mello TeraMaria Aparecida Neves Jardini
Feb 9, 2010·Journal of Dental Research·S LiuZ Bian
May 24, 2021·Clinical Oral Investigations·Birgit Rath-DeschnerAnna Damanaki
Aug 9, 2021·Archives of Oral Biology·Andressa V B NogueiraJoni A Cirelli
Jul 31, 2020·Archives of Oral Biology·Lanzhi Deng, Yongwen Guo
Mar 6, 2022·Journal of Periodontal Research·Maria Eduarda Scordamaia LopesAndressa Vilas Boas Nogueira

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.