Estrogen and antagonist-induced structural changes in the cervico-vaginal epithelium of immature rats.

The American Journal of Anatomy
W A Anderson, Y H Kang

Abstract

Estrogen enhances proliferation and keratin formation in the cervico-vaginal epithelium of immature rats, whereas the estrogen antagonist, CI-628 (Parke-Davis), represses mitosis and induces mucinogenesis. Combinations of antagonist and estrogen allow differentiation of an epithelium composed of both keratin-forming and mucous cells. Both estrogen and antagonist induce synthesis of a cervico-vaginal endogenous peroxidase in the intermediate and superficial layers of the epithelium. The secreted vaginal mucus of antagonist-treated animals stains intensely for exogenous peroxidase.

References

Mar 1, 1975·The Journal of Cell Biology·W A AndersonE R DeSombre
Jan 1, 1966·The Anatomical Record·T E Barker, B E Walker
Jan 1, 1972·Gynecologic Investigation·E V JensenE R De Sombre
Jun 1, 1972·The Anatomical Record·C F Bradley, C E Graham
Dec 1, 1965·Experimental Cell Research·J L Ladinsky, B M Peckham
Sep 1, 1955·The Journal of Experimental Medicine·C HUGGINS, E V JENSEN
Oct 1, 1963·The Anatomical Record·M E HUSBANDS, B E WALKER

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