Estrogen and bones after menopause: a reappraisal of data and future perspectives.

Hormones : International Journal of Endocrinology and Metabolism
Panagiotis AnagnostisI Lambrinoudaki

Abstract

Menopausal hormone therapy (MHT) is effective in preventing menopause-related bone loss and decreasing vertebral, non-vertebral and hip fracture risk. MHT contains estrogens that exert both antiosteoclastic and osteoanabolic effects. These effects are dose-dependent, as even ultra-low doses preserve or increase bone mineral density. The transdermal route of administration is effective on cancellous and cortical bone, although fracture data are still lacking. Hormone replacement therapy is the treatment of choice to preserve skeletal health in women with premature ovarian insufficiency and early menopause. MHT can be considered in women aged < 60 years or within 10 years since menopause as, in this population, benefits outweigh possible risks, such as breast cancer and cardiovascular events. Despite the ensuing bone loss after MHT discontinuation, a residual antifracture effect persists. However, in women at risk of fracture, subsequent antiosteoporotic therapy may be needed, either with an antiosteoclastic or osteoanabolic agent. In any case, longitudinal data from randomized controlled trials comparing different estrogen doses and routes of administration, as well as designating the optimal treatment strategy after MHT discont...Continue Reading

References

Jun 25, 1996·Biochemical and Biophysical Research Communications·H ManoM Kumegawa
Dec 1, 1996·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·G M PrelevicJ Ginsburg
Jul 14, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R HannonR Eastell
Sep 19, 2000·American Journal of Obstetrics and Gynecology·N H BjarnasonC Christiansen
Jul 11, 2001·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·F A TrémollieresC Ribot
Mar 26, 2002·Archives of Internal Medicine·Gail A GreendaleUNKNOWN PEPI Safety Follow-Up Study (PSFS) Investigators
May 22, 2002·JAMA : the Journal of the American Medical Association·Robert LindsayJames H Pickar
Jul 19, 2002·JAMA : the Journal of the American Medical Association·Jacques E RossouwUNKNOWN Writing Group for the Women's Health Initiative Investigators
Aug 28, 2003·JAMA : the Journal of the American Medical Association·Karen M PrestwoodMartin Kulldorff
Oct 2, 2003·JAMA : the Journal of the American Medical Association·Jane A CauleyUNKNOWN Women's Health Initiative Investigators
Apr 15, 2004·JAMA : the Journal of the American Medical Association·Garnet L AndersonUNKNOWN Women's Health Initiative Steering Committee
May 13, 2004·JAMA : the Journal of the American Medical Association·Emily BanksUNKNOWN Million Women Study Collaborators
May 5, 2005·Cytokine & Growth Factor Reviews·Rutger L van BezooijenClemens W G M Löwik
Oct 20, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Farhan A SyedSundeep Khosla
May 4, 2006·The Journal of Clinical Investigation·M Neale Weitzmann, Roberto Pacifici
Dec 8, 2007·Maturitas·Marco GambaccianiAndrea Riccardo Genazzani
Feb 23, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisE McCloskey
Jul 16, 2008·The Journal of Biological Chemistry·Nadiya M TeplyukAndre J van Wijnen
Jul 11, 2009·Climacteric : the Journal of the International Menopause Society·H MizunumaM Shiraki
Feb 17, 2010·The Journal of Clinical Endocrinology and Metabolism·Faryal S MirzaJoseph A Lorenzo
Jul 8, 2010·Maturitas·Svetlana VujovicUNKNOWN European Menopause and Andropause Society
Jul 22, 2011·Menopause : the Journal of the North American Menopause Society·Roksana KarimHoward N Hodis
Aug 5, 2011·Journal of Cellular Biochemistry·Jun Wang, Paula H Stern
Oct 7, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Gail A GreendaleArun S Karlamangla
Dec 12, 2012·The Journal of Clinical Investigation·Maria AlmeidaStavros C Manolagas
Feb 28, 2013·Molecular Endocrinology·Shoshana M BartellStavros C Manolagas
Jun 27, 2013·Menopause : the Journal of the North American Menopause Society·John A RobbinsJean Wactawski-Wende
Oct 8, 2015·The Journal of Clinical Endocrinology and Metabolism·Cynthia A StuenkelRichard J Santen
Nov 4, 2015·Menopause : the Journal of the North American Menopause Society·Linlin ZhuWenhuan Shu
Apr 5, 2016·The Journal of Clinical Investigation·Jing FuSuzanne Lentzsch
Jul 9, 2016·Maturitas·T J de VilliersD D Pierroz

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Citations

Feb 12, 2021·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Hideki InnanReiner A Veitia
Jul 31, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Alexander Kalinkovich, Gregory Livshits

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