Estrogen and cigarette sidestream smoke particulate matter exhibit ERα-dependent tumor-promoting effects in lung adenocarcinoma cells.

American Journal of Physiology. Lung Cellular and Molecular Physiology
Lun-Cheng KuoLih-Ann Li

Abstract

Estrogen and secondhand smoke are key risk factors for nonsmoking female lung cancer patients who frequently have lung adenocarcinoma and show tumor estrogen receptor α (ERα) expression. We speculated that estrogen and secondhand smoke might cause harmful effects via ERα signaling. Our results showed that 17β-estradiol (E2), the primary form of endogenous estrogen, exacerbated proliferation, migration, and granzyme B resistance of lung adenocarcinoma cells in an ERα-dependent manner. Cigarette sidestream smoke particulate matter (CSSP), the major component of secondhand smoke, could activate ERα activity dose dependently in human lung adenocarcinoma cells. The estrogenic activity of CSSP was abolished by an ERα-selective antagonist. CSSP regulated the nuclear entry, phosphorylation, and turnover of ERα similarly to E2. Furthermore, CSSP enhanced E2-stimulated ERα activity and Ser118 phosphorylation even when ERα became saturated with E2. Activation of ERα by CSSP required GSK3β activity, but not involving polycyclic aromatic hydrocarbons, reactive oxygen species, calcium, epidermal growth factor receptor, and PI3K/Akt. Although CSSP possessed cytotoxicity, ERα-expressing cells grew and migrated faster than nonexpressing cells o...Continue Reading

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Citations

Feb 20, 2019·Environmental Science and Pollution Research International·Li-Chuan ChengLih-Ann Li
Nov 16, 2020·The Journal of Steroid Biochemistry and Molecular Biology·Chi Sun LiauWarren Thomas
Jun 4, 2021·Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms·Li-Chuan ChengLih-Ann Li
Jul 20, 2021·Oncology Reports·Wen-Jun WangXiao-Qun Ye
Jul 11, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hongyan ZhangYanyan Zhao

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Methods Mentioned

BETA
xenografts
two-hybrid
transfection
chemical treatment
chemical treatments
PCR
nuclear translocation

Software Mentioned

MetaMorph
GenomeStudio

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