Estrogen and extinction of fear memories: implications for posttraumatic stress disorder treatment

Biological Psychiatry
Ebony M GloverSeth D Norrholm

Abstract

Posttraumatic stress disorder (PTSD) is a psychiatric illness whose prevalence in women is more than twice the rate as men. Despite a burgeoning literature characterizing sex differences in PTSD incidence and its disproportionate burden on society, there is a dearth of literature describing biological mechanisms underlying these disparities. However, the recent identification of biomarkers of PTSD by translational neuroscientists offers a promising opportunity to explore sex interactions in PTSD phenotypes. A notable observation is that individuals with PTSD show deficits in their ability to inhibit conditioned fear responding after extinction training. Given that extinction procedures, via exposure-based cognitive behavioral therapy, make up one of the predominant modes of treatment in PTSD, there is a critical need for more research on sex interactions in this form of fear regulation. An emerging hypothesis is that fluctuating gonadal hormones, especially estrogen, in the menstrual cycle may play a critical role in fear extinction and, hence, PTSD vulnerability and symptom severity in women. The current review discusses how the study of putative activational effects of estrogen on fear extinction may be harnessed to advance t...Continue Reading

References

May 1, 1992·The American Journal of Psychiatry·N Breslau, G C Davis
Aug 1, 1981·The British Journal of Psychiatry : the Journal of Mental Science·C Dean, R E Kendell
Dec 1, 1995·Archives of General Psychiatry·R C KesslerC B Nelson
Jan 1, 1994·Life Sciences·S Rivas-Arancibia, F Vazquez-Pereyra
Jun 21, 1997·Annals of the New York Academy of Sciences·A M Rasmusson, D S Charney
Jul 22, 1998·Archives of General Psychiatry·N BreslauP Andreski
Aug 15, 2000·American Journal of Obstetrics and Gynecology·P J SchmidtD R Rubinow
Mar 10, 2001·Progress in Neurobiology·M K Osterlund, Y L Hurd
Jan 16, 2002·Physiology & Behavior·F K MarcondesR C Spadari-Bratfisch
Nov 8, 2002·Nature·Mohammed R Milad, Gregory J Quirk
Nov 21, 2002·Neuron·Karyn M Myers, Michael Davis
Oct 18, 2003·The Psychiatric Clinics of North America·Teresa A Pigott
Mar 3, 2004·Annals of the New York Academy of Sciences·Hanna OstlundYasmin L Hurd
Apr 23, 2004·Psychophysiology·Tanja JovanovicErica J Duncan
Sep 15, 2004·Neuron·Elizabeth A PhelpsJoseph E LeDoux
May 20, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marissa I BoulwarePaul G Mermelstein
Jul 14, 2005·Neuroreport·Tracy ButlerDavid Silbersweig
Oct 7, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jill M GoldsteinNikos Makris
Jan 5, 2007·Behavioral Neuroscience·Mohammed R MiladScott L Rauch
Feb 23, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Cynthia Neill EppersonChristian Grillon
Jul 31, 2007·Brain Research Reviews·Michael J WeiserRobert J Handa
Dec 17, 2008·Neurobiology of Learning and Memory·Sarah E BaranCheryl D Conrad
Mar 12, 2009·Physiology & Behavior·Matia B Solomon, James P Herman
Jan 15, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jill M GoldsteinNikos Makris
Feb 10, 2010·Journal of Abnormal Psychology·Kim FelminghamRichard Bryant
Feb 10, 2010·Depression and Anxiety·Tanja JovanovicKerry J Ressler
Mar 17, 2010·The American Journal of Psychiatry·Tanja Jovanovic, Kerry J Ressler
May 7, 2010·Learning & Memory·Sarah E BaranCheryl D Conrad

❮ Previous
Next ❯

Citations

Apr 19, 2015·Hormones and Behavior·Lisa Y Maeng, Mohammed R Milad
Jun 28, 2016·Neurobiology of Learning and Memory·Georgina E FentonCarl W Stevenson
Jul 28, 2016·Neuroscience and Biobehavioral Reviews·Daniel V ZujKim L Felmingham
Oct 26, 2016·Translational Psychiatry·J S Milligan-Saville, B M Graham
Jan 21, 2017·Hormones and Behavior·Gillian M AccaNaomi Nagaya
Jan 18, 2017·The Australian and New Zealand Journal of Psychiatry·Jasmin GriggJayashri Kulkarni
Oct 2, 2017·Current Psychiatry Reports·Kristie Garza, Tanja Jovanovic
Mar 6, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Klara SpalekAnnette Milnik
Jun 25, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stephen Maren, Andrew Holmes
Sep 17, 2016·Learning & Memory·Ashley M BlouinCourtney A Miller
May 8, 2018·Harvard Review of Psychiatry·Seth Davin Norrholm, Tanja Jovanovic
Jun 7, 2019·International Journal of Molecular Sciences·Marangelie Criado-MarreroLaura J Blair
Feb 7, 2018·Journal of Psychopharmacology·Blanca Bolea-AlamanacRita Valentino
Oct 7, 2020·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Ida T FonkoueJeanie Park
May 16, 2018·Progress in Neuro-psychopharmacology & Biological Psychiatry·Bronwyn M Graham, Elliot Scott
Jan 6, 2021·International Journal of Molecular Sciences·Wu Jeong HwangJun Soo Kwon
Dec 16, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Antonia V SeligowskiKerry J Ressler
Feb 20, 2018·Current Opinion in Neurobiology·Itamar S Grunfeld, Ekaterina Likhtik
Mar 20, 2018·Journal of Affective Disorders·Sanju SilwalLars Lien

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.