PMID: 9557785Apr 29, 1998Paper

Estrogen and progesterone receptors in androgenic alopecia versus alopecia areata

The American Journal of Dermatopathology
M L Wallace, B R Smoller

Abstract

In some situations, hair growth is under hormonal control. Androgenic alopecia is characterized as hormonally driven hair loss in the genetically susceptible individual. During pregnancy, hair growth is increased, as estrogen appears to prolong the anagen phase. However, postpartum hair loss is common, and thus may be related to a decrease in estrogen and or progesterone levels. In contrast, alopecia areata is not considered to be under hormonal control. We compared the immunohistochemical staining characteristics of nine cases of androgenic alopecia with those of 13 cases of alopecia areata using estrogen receptor (ER) and progesterone receptor (PR) markers. Estrogen receptor positivity in the dermal papilla was found in only two of 13 cases of alopecia areata, and in one case of androgenic alopecia. Six of 13 cases of alopecia areata demonstrated focal reactivity with the progesterone marker in a similar location, while only three cases of androgenic alopecia showed positivity with this antibody. Examination of the perifollicular fibroblasts for the ER marker showed positivity in one of 13 cases of alopecia areata and in one case of androgenic alopecia. Two cases of alopecia areata revealed focal staining in this location for...Continue Reading

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Citations

Aug 5, 2000·Maturitas·M P Brincat
Jan 25, 2008·Gender Medicine·Harry Dao, Rebecca A Kazin
Apr 26, 2002·Veterinary Dermatology·Christine B Bratka-RobiaElmar Bamberg
Mar 16, 2001·The Journal of Perinatal & Neonatal Nursing·L Fuhrman
May 24, 2003·American Journal of Clinical Dermatology·Nicholas J Raine-FenningYves Muscat-Baron
Oct 21, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·G PelletierF Labrie
Oct 6, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·J Calleja-Agius, M Brincat
Aug 13, 2005·Climacteric : the Journal of the International Menopause Society·M P BrincatR Galea
Dec 8, 2006·Birth·Kathleen A CostiganJanet A DiPietro
Jan 26, 2006·Experimental Dermatology·Sylvie Verdier-SévrainBarbara Gilchrest
May 15, 2010·International Journal of Dermatology·Raquel Cristina Tancsik CordeiroAparecida Machado de Moraes
Sep 30, 2014·Molecular Genetics and Metabolism Reports·Jason J BisaillonThomas R King
May 6, 2019·The British Journal of Dermatology·R W ClaytonX Lim
Oct 21, 2000·Endocrine Reviews·A Slominski, J Wortsman

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