Estrogen and voluntary exercise attenuate cardiometabolic syndrome and hepatic steatosis in ovariectomized rats fed a high-fat high-fructose diet

American Journal of Physiology. Endocrinology and Metabolism
Jariya BuniamVitoon Saengsirisuwan

Abstract

The prevalence of cardiometabolic syndrome (CMS) is increased in women after menopause. While hormone replacement therapy has been prescribed to relieve several components of CMS in postmenopausal women, some aspects of cardiometabolic dysfunction cannot be completely restored. The present study examined the effectiveness of estrogen replacement alone and in combination with exercise by voluntary wheel running (VWR) for alleviating the risks of CMS, insulin-mediated skeletal muscle glucose transport, and hepatic fat accumulation in ovariectomized Sprague-Dawley rats fed a high-fat high-fructose diet (OHFFD). We compared a sham-operated group with OHFFD rats that were subdivided into a sedentary, estradiol replacement (E2), and E2 plus VWR for 12 wk. E2 prevented the development of insulin resistance in skeletal muscle glucose transport and decreased hepatic fat accumulation in OHFFD rats. Furthermore, E2 treatment decreased visceral fat mass and low-density lipoprotein (LDL)-cholesterol in OHFFD rats, while VWR further decreased LDL-cholesterol and increased the ratio of high-density lipoprotein-cholesterol to total cholesterol to a greater extent. Although E2 treatment alone did not reduce serum triglyceride levels in OHFFD ra...Continue Reading

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Citations

May 8, 2020·BMC Complementary Medicine and Therapies·Jariya BuniamVitoon Saengsirisuwan
Jul 31, 2020·Gene Expression·Debjyoti KunduHeather Francis
Oct 23, 2020·International Journal of Molecular Sciences·Xavier Remesar, Marià Alemany
Feb 23, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Zhensheng ZhangXiao Xu
Mar 20, 2021·Antioxidants & Redox Signaling·Andrea Morán-CostoyaAdamo Valle

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Methods Mentioned

BETA
hormone replacement therapy
Protein Assay

Software Mentioned

Image Studio
SPSS
ImageJ
CellSens

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