Estrogen binding sites in hamster white adipose tissue: sex- and site-related variations; modulation by testosterone

General and Comparative Endocrinology
A M JaubertY Giudicelli

Abstract

Estrogen binding sites (ER) were studied, using 17 beta-[3H]estradiol as the ligand, in epididymal or parametrial and subcutaneous adipose tissues of male and female hamsters. Compared with other mammalian fat deposits, intact male and female hamsters possess abundant estrogen binding sites with moderate affinity for estradiol and which occur as a single class of receptor in males but as two populations in females. The levels of estrogen receptors depend on both sex and tissue localization. In males, receptor densities are higher in both localizations when compared to those of females and ER are more abundant in superficial adipose deposits than in the deep fat tissue. In females, there are two estrogen binding populations; the one with the highest affinity is similar to the classical estrogen receptor and both populations are more abundant in deep fat than in subcutaneous deposits, in contrast to male hamsters. These characteristics depend on androgen status: in male adipose tissues, testosterone (TP) up-regulates the ER levels. Conversely, in female fat deposits, TP down-regulates the highest affinity estrogen receptors and the lowest affinity population disappears. Binding affinities are never affected by testosterone. These...Continue Reading

Citations

Nov 18, 2003·Diabetes, Obesity & Metabolism·A L HarteS Kumar
Jan 6, 2006·Environmental Health Perspectives·Jennifer A FentressAnn Oliver Cheek
Apr 19, 2003·Experimental Dermatology·M J ThorntonA G Messenger
Nov 5, 1997·General and Comparative Endocrinology·N L Staub, M De Beer
Jun 18, 2017·General and Comparative Endocrinology·Allison M BaileyGregory E Demas
Dec 22, 2019·The Journal of Experimental Biology·Clarissa C RenGregory E Demas
Sep 16, 2004·American Journal of Physiology. Endocrinology and Metabolism·S Rodriguez-CuencaP Roca
Aug 4, 2021·Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology·Allison M BaileyGregory E Demas

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