PMID: 8841486Sep 23, 1996Paper

Estrogen content and DNA unwinding in tumor and normal endometrial tissue of aging endometrial cancer patients

Mutation Research
L M Berstein Bokhman JaV


Over the past years, data on the role of DNA damage in hormonal carcinogenesis have been accumulated. In 21 endometrial cancer (EC) patients (mean age 61.8 +/- 1.6 years), no difference between malignant and normal endometrium in estradiol content (radioimmunological assay) and in alkali-induced DNA unwinding as a measure of DNA strand breakage (fluorometrical assay) was discovered. At the same time (contrary to normal endometrium), there were no correlations between the estradiol content in malignant endometrium with DNA unwinding or blood estrogen level. The estradiol concentration in malignant endometrium increases with age in menopausal EC patients, though no correlation between estrogen content in endometrial tissue and body weight was discovered. DNA unwinding rate in malignant endometrium correlates only with the concentration of steroid receptors in normal endometrial tissue. It may be possible that before the appearing of any neoplastic changes in the endometrium, a higher level of estradiol in the target tissue leads to DNA damage which may be considered as a factor predisposing to tumor development. Practically speaking this would mean that the estradiol content and DNA unwinding level in endometrial tumors may be us...Continue Reading


May 1, 1990·Mutation Research·J G Liehr
May 1, 1986·Journal of Steroid Biochemistry·C Vermeulen-MeinersJ H Thijssen
Feb 1, 1973·The Journal of Clinical Endocrinology and Metabolism·J M GrodinP C MacDonald
Nov 1, 1982·The Journal of Clinical Endocrinology and Metabolism·L TsengJ Chumas
Jan 1, 1994·Archives of Gynecology and Obstetrics·O GemerS Segal
Jan 29, 1993·Science·B E HendersonM C Pike
Mar 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·T YamamotoY Terashima

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