PMID: 6413811Nov 1, 1983Paper

Estrogen dependence of the periovulatory plasma prolactin response to gonadotropin-releasing hormone in normal women

Metabolism: Clinical and Experimental
A BarbarinoS Minnielli

Abstract

It has been previously reported that GnRH is capable of inducing a PRL response in intact and castrated men treated with estradiol benzoate for 8-9 days. To further support the hypothesis of an estrogen-dependence of the PRL response to GnRH, GnRH was administered, either as a bolus or as a continuous infusion, to 45 normal women during various phases of their menstrual cycles. Synthetic GnRH (100 micrograms intravenous bolus) elicited a significant increase (mean 175%) in circulating PRL levels in nine women studied during the periovulatory phase of the menstrual cycle (days 14-17). Similarly, GnRH infusion (0.2 micrograms/min X 3 h) induced a PRL response (mean 148%) in six women studied during the same period. In contrast, saline infusion induced a modest decrease (37%) in plasma PRL levels in five women studied during the periovulatory period. No significant changes in circulating PRL levels were found after GnRH administration as a bolus or a continuous infusion, in 13 women during the late follicular phase (days 10-13) and in 12 women during the midluteal phase (days 21-24). Synthetic GnRH elicited the expected increase in gonadotropin levels during all phases of the cycle studied. The maximal response was found for both ...Continue Reading

References

Jul 1, 1979·The Journal of Clinical Endocrinology and Metabolism·O GiampietroI Brunori
Sep 1, 1976·The Journal of Clinical Endocrinology and Metabolism·A CataniaE Reschini
Dec 1, 1972·The Journal of Clinical Endocrinology and Metabolism·S S YenY Ehara
Jan 1, 1973·The Journal of Clinical Endocrinology and Metabolism·R RebarR Guillemin
Feb 1, 1973·The Journal of Clinical Endocrinology and Metabolism·A J KastinA V Schally
Sep 1, 1972·The Journal of Clinical Endocrinology and Metabolism·G O DeVillaG Flickinger
Aug 1, 1980·The Journal of Clinical Endocrinology and Metabolism·A Barbarino, L De Marinis
Dec 1, 1982·The Journal of Clinical Endocrinology and Metabolism·A BarbarinoC Farabegoli
Jun 9, 1980·Life Sciences·S S YemK Sheehan

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Citations

Oct 1, 1986·Immunopharmacology·E Nagy, I Berczi
Jan 1, 1988·Psychoneuroendocrinology·L De MarinisA Barbarino
Jul 13, 2002·Annals of the New York Academy of Sciences·S LeidermanA Maccagno

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