Estrogen deprivation in primate pregnancy leads to insulin resistance in offspring

The Journal of Endocrinology
Adina ManiuE D Albrecht

Abstract

This study tested the hypothesis that estrogen programs mechanisms within the primate fetus that promote insulin sensitivity and glucose homeostasis in offspring. Glucose tolerance tests were performed longitudinally in prepubertal offspring of baboons untreated or treated on days 100 to 165/175 of gestation (term is 184 days) with the aromatase inhibitor letrozole, which decreased fetal estradiol levels by 95%. Basal plasma insulin levels were over two-fold greater in offspring delivered to letrozole-treated than untreated animals. Moreover, the peak 1min, average of the 1, 3, and 5min, and area under the curve blood glucose and plasma insulin levels after an i.v. bolus of glucose were greater (P<0.05 and P<0.01, respectively) in offspring deprived of estrogen in utero than in untreated animals and partially or completely restored in letrozole plus estradiol-treated baboons. The value for the homeostasis model assessment of insulin resistance was 2.5-fold greater (P<0.02) and quantitative insulin sensitivity check index lower (P<0.01) in offspring of letrozole-treated versus untreated animals and returned to almost normal in letrozole plus estradiol-treated animals. The exaggerated rise in glucose and insulin levels after gluc...Continue Reading

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Citations

Mar 27, 2019·Journal of Cellular Physiology·Chuanfeng TangLiang Sheng
Jul 18, 2018·The Journal of Endocrinology·Sara Della TorreAdriana Maggi
Dec 19, 2019·Frontiers in Endocrinology·Ziqiang ZhuXiaozhong Li
Jun 8, 2019·Reproductive Toxicology·Barbara A Cohn, Piera M Cirillo
Apr 17, 2021·Investigative Ophthalmology & Visual Science·Danielle A Clarkson-TownsendMachelle T Pardue

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