Estrogen effects on MMP-13 and MMP-14 regulation of left ventricular mass in Dahl salt-induced hypertension.

Gender Medicine
Qiuxia DaiMerry L Lindsey

Abstract

Female Dahl salt-sensitive (DS) rats fed a low-salt diet develop hypertension at 6 months of age. Ovariectomy at 2 months of age accelerates the development of hypertension, and estrogen replacement delays it. Although acute pressure overload induces structural changes in the left ventricle (LV) further effects of gradual hypertension on LV remodeling have not been examined in the DS rat model. The purpose of this study was to test the hypothesis that aging and estrogen loss in hypertensive DS rats are accompanied by changes in LV remodeling. Four groups of DS rats were examined: young intact, middle-aged (MA) intact, MA ovariectomized (MA-OVX), and MA-OVX with 17beta-eestradiol (E(2)) supplementation (MA-OVX+E(2)). Myocardial matrix metalloproteinases (MMPs),tissue inhibitors of metalloproteinases (TIMPs),and extracellular matrix (ECM) proteins were assessed by immunoblotting. Each of the 4 groups comprised 6 animals. Mean (SEM) LV mass was significantly greater in the MA-intact and the MA-OVX groups (1257 [31] mg and 1199 [25] mg, respectively; both, P < 0.05) compared with the young-intact group (697 [6] mg). LV mass in the MA-OVX+E(2) group was significantly lower compared with the MA-intact and MA-OVX groups (both, P < 0.0...Continue Reading

References

Jun 1, 1992·Journal of the American College of Cardiology·A GanauJ H Laragh
Apr 1, 1990·Obstetrics and Gynecology·R A Lobo
Jun 11, 1999·The New England Journal of Medicine·M E Mendelsohn, R H Karas
Jul 10, 1999·Journal of the American College of Cardiology·E O WeinbergB H Lorell
Jun 9, 2000·Kidney International·G C ShearerG A Kaysen
Feb 28, 2002·Cardiovascular Research·Raghvendra K DubeyEdwin K Jackson
Feb 5, 2003·Cardiovascular Research·Yi XuSandra T Davidge
Jan 24, 2004·Heart Failure Reviews·Merry L Lindsey
May 22, 2004·Journal of the American Society of Nephrology : JASN·Christine MaricCarmen Hinojosa-Laborde
Sep 1, 2004·Hypertension·Carmen Hinojosa-LabordeKathryn Sandberg
Nov 4, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Saumya SharmaHeinrich Taegtmeyer
Nov 16, 2004·Journal of Vascular Research·Joost P G SluijterDominique P V de Kleijn
May 5, 2005·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·M Schlieter, B Kress
Jul 22, 2005·Physiological Genomics·Beverly A RothermelJoseph A Hill
Nov 22, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Jasmina VaragicBegoña López
Aug 11, 2006·Climacteric : the Journal of the International Menopause Society·T Simon

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Citations

Apr 22, 2015·Molecular and Cellular Biochemistry·Hao WangLeanne Groban
Jan 5, 2013·Circulation Research·Francis G SpinaleMichael R Zile
May 28, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Tetyana G Voloshenyuk, Jason D Gardner
Oct 23, 2016·American Journal of Physiology. Heart and Circulatory Physiology·M C El HajjJ D Gardner
Dec 15, 2021·Menopause : the Journal of the North American Menopause Society·Tshiamo T MalulekeFrédéric S Michel

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