Estrogen enhances angiogenesis through a pathway involving platelet-activating factor-mediated nuclear factor-kappaB activation

Cancer Research
Kook Heon SeoSuhn-Young Im

Abstract

In this study, we investigated the molecular events involved in estrogen-induced angiogenesis. Treatment of the human endometrial adenocarcinoma cells, HEC-1A, with estrogen up-regulated mRNA expression and protein synthesis of various angiogenic factors such as tumor necrosis factor-alpha, interleukin-1, basic fibroblast growth factor, and vascular endothelial growth factor. The estrogen-dependent induction of the expression was blocked by the platelet-activating factor (PAF) antagonists, WEB 2170. Estrogen treatment caused the activation of nuclear factor (NF)-kappaB in HEC-1A cells and was also blocked by PAF antagonist. Inhibitors of NF-kappaB activation inhibited estrogen-induced mRNA expression and protein synthesis of the angiogenic factors. Estrogen led to a pronounced angiogenesis as assessed by a mouse Matrigel model in vivo and endothelial cell sprouting in vitro. PAF antagonists or NF-kappaB inhibitors significantly inhibited this estrogen-dependent angiogenesis. Estrogen caused phospholipase A2 (PLA2) gene and protein expression. Estrogen-induced vascular endothelial growth factor mRNA expression and sprouting were significantly inhibited by PLA2 inhibitors, suggesting PLA2 expression is the upstream pathway in the...Continue Reading

References

Mar 1, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S D Shukla
Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·G Shyamala, M C Guiot
May 1, 1995·Free Radical Research·T M Buttke, P A Sandstrom
Jan 1, 1994·Annual Review of Immunology·P A Baeuerle, T Henkel
Jan 29, 1993·Cell·L L LinR J Davis
Jul 1, 1993·Journal of Cellular Physiology·J C Gay
Apr 2, 1996·Proceedings of the National Academy of Sciences of the United States of America·R A StoltzM Laniado-Schwartzman
Jan 1, 1997·Trends in Biochemical Sciences·E A Dennis
Jan 1, 1997·Critical Reviews in Immunology·M MurakamiI Kudo
Oct 6, 1997·The Journal of Biological Chemistry·D ChilovK Alitalo
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·P Bhat-NakshatriH Nakshatri
Nov 6, 1998·The Journal of Experimental Medicine·I H ChoiH K Lee
Jan 7, 1999·The Journal of Steroid Biochemistry and Molecular Biology·G CerilloM Needham
Jun 23, 2000·The Journal of Clinical Investigation·K AbeyamaA Takashima
Jul 29, 2000·Journal of Molecular Endocrinology·S E BulunH Sasano
Jan 9, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·D W Losordo, J M Isner
Apr 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J H ChoiS Y Im
Oct 27, 2001·Circulation Research·M J EvansD C Harnish
Mar 19, 2002·The Journal of Steroid Biochemistry and Molecular Biology·Richard J SantenWei Yue
Feb 27, 2003·The Journal of Investigative Dermatology·Naoko Kanda, Shinichi Watanabe

❮ Previous
Next ❯

Citations

Mar 28, 2007·Pathology Oncology Research : POR·Judit KissAndrea Ladányi
Aug 28, 2007·Cancer Metastasis Reviews·Vladislava Melnikova, Menashe Bar-Eli
Apr 13, 2010·Clinical & Experimental Metastasis·Adriana AlbiniUlrich Pfeffer
Jul 27, 2006·Pancreas·Makoto SatakeGuido Eibl
Mar 27, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Hee Sun ParkYong Chul Lee
May 15, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Olga V GlinskiiVladislav V Glinsky
Dec 18, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Manish I PatelQihan Dong
Oct 7, 2005·Arthritis Research & Therapy·Maurizio CutoloBarbara Villaggio
Feb 18, 2009·PloS One·Lei ChengMing Li
Oct 4, 2012·Cytokine & Growth Factor Reviews·Jermaine I G Coward, Hagen Kulbe
May 27, 2005·British Journal of Haematology·Christine F SkibolaEve Roman
Apr 16, 2016·Nature Reviews. Cancer·Andrea ClocchiattiG Paolo Dotto
Feb 21, 2009·International Journal of Cancer. Journal International Du Cancer·Dong Soon ChoiHee-Sug Ryu
Jan 18, 2014·American Journal of Clinical Pathology·Carlos Chaves FaloppaFernando Augusto Soares
Mar 5, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Ying ChenXiang-Yu Liu
May 24, 2006·World Journal of Gastroenterology : WJG·Muriel MathonnetYves Denizot
May 3, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nam-In KangHern-Ku Lee
Nov 28, 2020·Scientific Reports·Julia SpielmannHeike Kielstein
Dec 19, 2006·Molecular Cancer Therapeutics·Yelena B WetherillKaren E Knudsen
Oct 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sophie DoublierGiovanni Camussi
May 13, 2021·Journal of Applied Toxicology : JAT·Adam HargreavesShirley Price
Sep 6, 2013·Gynecologic Oncology·Tormund S NjølstadJone Trovik

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.