Estrogen enhances secretion of apolipoprotein B-100 containing lipoproteins by BeWo cells

Biochimie
Miriam KamperMarcela Hermann

Abstract

Although the early human embryo is capable of covering its cholesterol demand by endogenous synthesis, during later stages of development the fetus may become dependent on transplacental cholesterol transport. On one hand, this conclusion is based on the severe developmental abnormalities of embryos with mutations in the gene specifying the enzyme catalyzing the last step of cholesterol synthesis, 7-dehydrocholesterol reductase, causing Smith-Lemli-Opitz Syndrome. On the other hand, increased total maternal plasma cholesterol levels may reflect the requirement by the growing fetus and/or the placenta for cholesterol. Various molecules and complexes must cross the placental barrier consisting of trophoblasts and fetal endothelial cells to reach the fetal circulation. The de novo synthesis of apolipoprotein B (apoB)-containing lipoproteins coupled to secretion from trophoblasts towards the fetal side is one efficient pathway for cholesterol supply. ApoB and the microsomal triglyceride transfer protein (MTP) are essential components for the assembly of apoB-containing lipoproteins. The aim of this study was to evaluate functional properties of the human placental cell line BeWo as an in vitro model for placental synthesis of apoB-...Continue Reading

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Citations

Jan 30, 2016·BMC Genetics·Xuemin WangXiaoping Li
Apr 19, 2019·Scientific Reports·Hassan MelhemChristiane Albrecht
Dec 22, 2019·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Loredana QuadroM Mahmood Hussain

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