Estrogen has mnemonic-enhancing effects in the inhibitory avoidance task

Pharmacology, Biochemistry, and Behavior
M E Rhodes, Cheryl A Frye

Abstract

Gonadal hormones, such as estrogen, can alter cognitive performance. The present studies investigated the relationship between performance on the inhibitory avoidance task and endogenous fluctuations in ovarian hormones and estrogen replacement. In Experiment 1, proestrous or diestrous I female, or male, rats were trained in the inhibitory avoidance task. Following a 24-h intertrial delay, when female rats were tested in metestrus or diestrus II, no differences in crossover latencies were observed among groups. In Experiment 2, female rats in proestrus or diestrus I, and male rats, were trained in the inhibitory avoidance task and were tested following a 4-h intertrial delay (so that training and testing were accomplished in the same phase of the cycle). In this paradigm, proestrous rats had significantly longer crossover latencies than did either diestrous I or male rats. Posttraining administration of estrogen, but not progesterone, to ovariectomized rats increased crossover latencies compared to vehicle with a 4-h (Experiment 3) or 24-h (Experiment 4) intertrial delay. In Experiment 5, estrogen administration to ovariectomized rats immediately, but not 1, 2, or 3 h posttraining, increased crossover latencies compared to vehi...Continue Reading

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Citations

Oct 19, 2011·Behavioral Neuroscience·Tehila Eilam-StockVictoria Luine
Mar 24, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alicia A Walf, Cheryl A Frye
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Apr 29, 2008·Neuroscience Letters·Cheryl A Frye, Alicia A Walf
Nov 9, 2007·Neurobiology of Learning and Memory·Cheryl A Frye, Alicia A Walf
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Nov 30, 2019·Frontiers in Behavioral Neuroscience·Anousheh Bakhti-SurooshWendy J Lynch
Mar 26, 2009·Learning & Memory·Joseph M Andreano, Larry Cahill

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