Estrogen improved metabolic syndrome through down-regulation of VEGF and HIF-1α to inhibit hypoxia of periaortic and intra-abdominal fat in ovariectomized female rats.

Molecular Biology Reports
Jinwen XuTinghuai Wang

Abstract

Metabolic syndrome (MBS), a cluster of metabolic abnormalities and visceral fat accumulation, increases cardiovascular risks in postmenopausal women. In addition to visceral fat, perivascular adipose tissue has been recently found to play an important role in vascular pathophysiology. Hence, the present study investigates the effects of estrogen on both intra-abdominal fat (visceral fat) and periaortic fat (perivascular fat) accumulation as well as hypoxia in ovariectomized female rats. Female rats were divided into sham operation, ovariectomy and ovariectomy with 17β-estradiol supplementation groups. Twelve weeks later, we found that estrogen improved MBS via reducing body weight gain, the weight of periaortic and intra-abdominal fat, hepatic triglyceride, and total serum cholesterol levels. Estrogen also increased insulin sensitivity through restoring glucose and serum leptin levels. For periaortic fat, western blot showed estrogen inhibited hypoxia by reducing the levels of VEGF and HIF-1α, which is consistent with the results from immunohistochemical staining. The correlation analysis indicated that perivascular fat had a positive correlation with body weight, intra-abdominal fat or serum total cholesterol, but a negative c...Continue Reading

References

Jan 1, 1991·Clinical and Experimental Hypertension. Part A, Theory and Practice·E E Soltis, L A Cassis
Oct 6, 2000·The Journal of Clinical Investigation·G L Semenza
Jun 28, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Matthias LöhnArya M Sharma
Dec 4, 2002·JAMA : the Journal of the American Medical Association·Hanna-Maaria LakkaJukka T Salonen
Sep 18, 2003·Nature Reviews. Cancer·Gregg L Semenza
Nov 9, 2004·Trends in Pharmacological Sciences·Maik Gollasch, Galyna Dubrovska
Jul 19, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Christine BarandierZhihong Yang
Apr 8, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Beatriz GálvezMaria S Fernández Alfonso
Jun 8, 2006·Cardiovascular Research·Yu-Jing GaoRobert M K W Lee
Apr 7, 2007·Menopause : the Journal of the North American Menopause Society·Dominik RachońWolfgang Wuttke
Jul 10, 2007·Cardiovascular Research·Gábor FésüsMaik Gollasch
Jul 13, 2007·Trends in Biochemical Sciences·Sonia Rocha
Aug 8, 2007·Journal of the Cardiometabolic Syndrome·Naftali Stern, Yonit Marcus
Oct 27, 2007·Climacteric : the Journal of the International Menopause Society·R A Lobo
Nov 30, 2007·Medicine and Science in Sports and Exercise·Matthew S ReifenbergerM Harold Laughlin
Dec 18, 2007·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Marcin MalinowskiStanisław Woś
Apr 10, 2008·The British Journal of Nutrition·Paul TrayhurnI Stuart Wood
May 10, 2008·Menopause : the Journal of the North American Menopause Society·Geum Joon ChoSun Haeng Kim
Jul 30, 2008·Archives of Internal Medicine·Imke JanssenKim Sutton-Tyrrell
Sep 10, 2008·Menopause : the Journal of the North American Menopause Society·Kim E InnesAnn Gill Taylor
Dec 4, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J Ye
Jan 6, 2009·Circulation Research·Mary DrinaneMary Jo Mulligan-Kehoe
Jan 6, 2009·Circulation Research·Tapan K ChatterjeeNeal L Weintraub
Jan 14, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C L SchlettU Hoffmann
Feb 28, 2009·Circulation Research·Scott T Robinson, W Robert Taylor
Mar 7, 2009·Medical Hypotheses·Matti Järvilehto, Pentti Tuohimaa
Jun 24, 2009·Molecular and Cellular Biology·Nils HalbergPhilipp E Scherer
Aug 7, 2009·Climacteric : the Journal of the International Menopause Society·A PighonJ-M Lavoie
Sep 19, 2009·Circulation Research·Minoru TakaokaMasataka Sata
Nov 3, 2010·Menopause : the Journal of the North American Menopause Society·Angelo CagnacciAnnibale Volpe

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Citations

Nov 19, 2013·PloS One·Matthias R MeyerEric R Prossnitz
Jul 17, 2019·Sleep & Breathing = Schlaf & Atmung·Lixiu ZhangXiaohong Lv
Aug 28, 2020·Molecular and Cellular Biochemistry·Jml Medina-ContrerasJ Balderas-Villalobos
Jan 28, 2014·Asian Pacific Journal of Tropical Medicine·Shan BaoGe-Bo Wen
Sep 22, 2017·Metabolic Syndrome and Related Disorders·Run-Mei LiJin-Wen Xu
May 12, 2016·Acta Cirúrgica Brasileira·Raif Restivo SimãoLuiz Felipe Pinho Moreira
Jul 3, 2020·Current Pharmaceutical Design·Jamaira A VictorioAna P Davel
May 8, 2019·Journal of Medicinal Chemistry·Donald PoirierDiana Ayan
May 6, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sui-Qing ChenRun-Mei Li

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