Estrogen in prefrontal cortex blocks stress-induced cognitive impairments in female rats

The Journal of Steroid Biochemistry and Molecular Biology
Eunice Y YuenZhen Yan

Abstract

Animal and human studies have found that males and females show distinct stress responses. Recent studies suggest the contribution of estrogen in the brain to this sexual dimorphism. Repeated stress has been found to impair cognitive behaviors via suppressing glutamatergic transmission and glutamate receptor surface expression in pyramidal neurons of prefrontal cortex (PFC) in male rats. On the contrary, female rats exposed to the same stress paradigms show normal synaptic function and PFC-mediated cognition. The level of aromatase, the enzyme for the biosynthesis of estrogen, is significantly higher in the PFC of females than males. The stress-induced glutamatergic deficits and memory impairment are unmasked by blocking estrogen receptors or aromatase in females, suggesting a protective role of estrogen against the detrimental effects of repeated stress.

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Citations

Aug 8, 2018·Cellular and Molecular Neurobiology·Maria Elvira Brocca, Luis Miguel Garcia-Segura
Sep 10, 2019·Climacteric : the Journal of the International Menopause Society·Y-C Chen, W-Z Sun
Mar 25, 2021·The European Journal of Neuroscience·Angeliki VelliKyriaki Sidiropoulou
May 1, 2021·Psychoneuroendocrinology·Tyler WallaceBrent Myers
Jun 6, 2021·Frontiers in Neuroendocrinology·Miriam PillerováĽubomíra Tóthová
Aug 24, 2021·Frontiers in Behavioral Neuroscience·Iryna S Palamarchuk, Tracy Vaillancourt

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