Estrogen-induced gonadotropin surges in female rhesus monkeys after pituitary stalk section

M FerinR L Vande Wiele


In order to investigate the primary site of action of estradiol, whether pituitary or hypothalamic, gonadotropin responses to estrogen were studied in female rhesus monkeys before and immediately after pituitary stalk section. The estrogen challenge, consisting of either an injection of estradio benzoate (400 microgram) or an implant of three silastic capsules containing 17 beta-estradiol, was initiated on days 2--5 of the menstrual cycle. The estrogen was given not later than 8 h after stalk section. Estrogens induced LH surges in all five animals before and after stalk section. FSH increases were observed in four of five intact and three of four stalk-sectioned animals. Mean FSH and LH levels in three stalk-sectioned animals treated with oil alone did not differ significantly from preinjection controls. These experiments suggest that the locus of estrogens on gonadotropin release in the rhesus monkey may well reside within the pituitary gland itself.


Jul 1, 1979·Journal of Steroid Biochemistry·M Ferin
Oct 1, 1980·European Journal of Obstetrics, Gynecology, and Reproductive Biology·P F Van Look, D T Baird
Apr 1, 1996·European Journal of Obstetrics, Gynecology, and Reproductive Biology·G Leyendecker, L Wildt
Nov 1, 1983·Clinics in Endocrinology and Metabolism·P E Belchetz
Nov 1, 1987·Journal of Adolescent Health Care : Official Publication of the Society for Adolescent Medicine·E O Reiter
May 5, 2006·Human Reproduction Update·Ioannis E Messinis
Feb 13, 2001·Endocrine Reviews·E Terasawa, D L Fernandez

Related Concepts

Estradiol, (16 alpha,17 beta)-Isomer
Menstrual Cycle, Proliferative Phase
Follicle Stimulating Hormone
Organum Vasculosum Laminae Terminalis
Macaca mulatta
Pituitary Stalk

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