Estrogen-induced inhibition of spermatogenesis in zebrafish is largely reversed by androgen

Journal of Molecular Endocrinology
Luiz Henrique de Castro AssisRüdiger W Schulz

Abstract

The hormonal regulation of spermatogenesis involves both gonadotropins and steroid hormones. Long-term in vivo exposure of adult zebrafish to estrogen impaired spermatogenesis associated with an androgen insufficiency, possibly induced by inhibiting gonadotropin release. Using this experimental model, we investigated if androgen treatment could enhance spermatogenesis, while maintaining the inhibition of gonadotropin release through continued estrogen exposure. Moreover, we also exposed animals to androgen alone, in order to examine androgen effects in the absence of estrogen-induced gonadotropin inhibition. Estrogen exposure depleted type B spermatogonia, meiotic and postmeiotic germ cells from the adult testis, but promoted the proliferation of type A undifferentiated spermatogonia, which accumulated in the testis. This change in germ cell composition was accompanied by reduced mRNA levels of those growth factors (e.g. insl3 and igf3) expressed by testicular somatic cells and known to stimulate spermatogonial differentiation in zebrafish. Additional androgen (11-ketoandrostenedione, which is converted to 11-ketotestosterone) treatment in vivo reversed most of the effects of estrogen exposure on spermatogenesis while insl3 and...Continue Reading

References

May 1, 1991·General and Comparative Endocrinology·R Schulz, V Blüm
Dec 9, 1998·Journal of Molecular Endocrinology·J T Dickey, P Swanson
Oct 21, 1999·Biochemical and Biophysical Research Communications·T MiuraK Yamauchi
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Apr 11, 2003·Environmental Toxicology and Chemistry·Leo T M van der VenJeff G Vos
Aug 7, 2004·Molecular Endocrinology·Patricia I Sadate-NgatchouMichael D Griswold
Dec 15, 2004·International Journal of Andrology·Robert W Holdcraft, Robert E Braun
Apr 16, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Theodore A CraigRajiv Kumar
May 13, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·P P de WaalJ Bogerd
Mar 21, 2009·General and Comparative Endocrinology·Marcelo C LealRüdiger W Schulz
Apr 8, 2009·General and Comparative Endocrinology·Rüdiger W SchulzTakeshi Miura
Sep 24, 2010·PloS One·Rafael Henrique NóbregaRüdiger W Schulz
May 20, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Kenji SaitoNoriyoshi Sakai
Sep 26, 2012·International Journal of Evolutionary Biology·Sara GoodJan Bogerd
Jan 31, 2013·General and Comparative Endocrinology·Shi X ChenRüdiger W Schulz
Jan 30, 2014·Proceedings of the National Academy of Sciences of the United States of America·François ChauvignéJoan Cerdà
Apr 2, 2014·Seminars in Cell & Developmental Biology·Stefan Schlatt, Jens Ehmcke
Dec 2, 2014·General and Comparative Endocrinology·Michelle C MeloRüdiger W Schulz
Jun 17, 2015·Cell and Tissue Research·L H C AssisR W Schulz
Jul 25, 2015·Endocrinology·Rafael Henrique NóbregaJan Bogerd

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Citations

Apr 5, 2019·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Alejandro ValdiviesoFrancesc Piferrer
Jan 20, 2020·Cellular and Molecular Life Sciences : CMLS·Minghui LiDeshou Wang
Aug 15, 2020·Frontiers in Endocrinology·Michelle ThönnesFrank Pfennig
Dec 5, 2020·Biology of Reproduction·Yuxin XieChristopher H K Cheng

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