Estrogen induces EGR1 to fine-tune its actions on uterine epithelium by controlling PR signaling for successful embryo implantation

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Hye-Ryun KimHaengseok Song

Abstract

The harmonized actions of ovarian E2 and progesterone (P4) regulate the proliferation and differentiation of uterine cells in a spatiotemporal manner. Imbalances between these hormones often lead to infertility and gynecologic diseases. Whereas numerous factors that are involved in P4 signaling have been identified, few local factors that mediate E2 actions in the uterus have been revealed. Here, we demonstrate that estrogen induces the transcription factor, early growth response 1 ( Egr1), to fine-tune its actions in uterine epithelial cells (ECs) that are responsible for uterine receptivity for embryo implantation. In the presence of exogenous gonadotrophins, ovulation, fertilization, and embryonic development normally occur in Egr1-/- mice, but these animals experience the complete failure of embryo implantation with reduced artificial decidualization. Although serum levels of E2 and P4 were comparable between Egr1+/+ and Egr1-/- mice on d 4 of pregnancy, aberrantly reduced levels of progesterone receptor in Egr1-/- uterine ECs caused enhanced E2 activity and impaired P4 response. Ultrastructural analyses revealed that Egr1-/- ECs are not fully able to provide proper uterine receptivity. Uterine mRNA landscapes in Egr1-/- mi...Continue Reading

References

Apr 28, 1995·The Journal of Biological Chemistry·S L LeeJ Milbrandt
Apr 1, 1995·Molecular and Cellular Biology·A H Swirnoff, J Milbrandt
Jan 24, 1998·Molecular Endocrinology·P TopilkoP Charnay
Jun 12, 1998·Biology of Reproduction·M M DeSouzaD D Carson
May 18, 1999·The Journal of Biological Chemistry·S F YanD M Stern
Sep 9, 2004·Cell Research·Christopher R Murphy
Apr 20, 2005·The Journal of Cell Biology·Y'vonne AlbertWarren G Tourtellotte
Jan 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Srinivasa Raju MantenaMilan K Bagchi
May 15, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jae-Wook JeongFrancesco J DeMayo
Dec 14, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Heather L FrancoFrancesco J Demayo
Dec 4, 2012·International Journal of Molecular Sciences·Judith-Irina Pagel, Elisabeth Deindl
Nov 23, 2013·PLoS Medicine·Allison JonesMartin Widschwendter
Jan 4, 2015·Steroids·Susan B Brown, Susan E Hankinson
Sep 1, 2015·Prostaglandins & Other Lipid Mediators·Na HuangJinshan Cao

❮ Previous
Next ❯

Citations

Jul 18, 2019·Reproductive Medicine and Biology·Yamato FukuiYutaka Osuga
Aug 8, 2019·International Journal of Molecular Sciences·Ryan M MarquardtJae-Wook Jeong
Nov 23, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ryan M MarquardtJae-Wook Jeong
Oct 20, 2020·Journal of Gynecology Obstetrics and Human Reproduction·Candan EkerTuba Gunel
Mar 13, 2021·Proceedings of the National Academy of Sciences of the United States of America·Mary C PeaveyFrancesco J DeMayo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.