Estrogen induces insulin-like growth factor-I expression in the rat uterus

Molecular Endocrinology
L J MurphyH G Friesen

Abstract

The inability to convincingly demonstrate a mitogenic effect of estrogen on isolated uterine cells in culture suggests that autocrine or paracrine growth factors may be important in the estrogen-induced uterine proliferative response. Here we report that uterine expression of insulin-like growth factor-I (IGF-I), an important mediator of GH action, is increased after 17 beta-estradiol (5 micrograms/100 g bw, ip) administration to ovariectomized prepubertal rats. An increase in uterine IGF-I mRNA abundance, approximately 14-fold above untreated controls, was apparent 6 h after estrogen administration and the level achieved exceeded that seen in the uterus from intact mature rats during diestrus. In contrast to the increase in IGF-I expression in the uterus, no significant change in serum IGF-I concentration or hepatic or renal IGF-I mRNA abundance was demonstrable after 17 beta-estradiol injection of ovariectomized prepubertal rats. The increase in uterine IGF-I expression, was similar in both pituitary-intact and hypophysectomized, ovariectomized rats. We believe this is the first report of induction of IGF-I expression by estrogen in vivo. As such, the finding expands the role and significance of IGF-I as a mediator of growth ...Continue Reading

Citations

Mar 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P E KeetingB L Riggs
Jun 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G A Rodan
Jul 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A GouldingN J Lewis-Barned
Mar 1, 1992·Molecular Reproduction and Development·M B Harvey, P L Kaye
Sep 1, 1993·Molecular Reproduction and Development·G F Dunglison, P L Kaye
Jan 1, 1994·Breast Cancer Research and Treatment·L C Murphy
Apr 1, 1997·Journal of Assisted Reproduction and Genetics·M TagaH Minaguchi
Jan 1, 1989·Journal of Steroid Biochemistry·M ErnstG A Rodan
Apr 1, 1989·Trends in Pharmacological Sciences·P G ZaphiropoulosJ A Gustafsson
Jun 1, 1989·Molecular and Cellular Endocrinology·L J Murphy, J M Luo
May 11, 1991·Molecular and Cellular Endocrinology·D LeRoith, C T Roberts
May 1, 1991·Molecular and Cellular Endocrinology·B Carlsson, H Billig
Mar 1, 1992·Molecular and Cellular Endocrinology·C A Beck, C W Garner
Sep 1, 1992·Molecular and Cellular Endocrinology·C VuillermozG L Adessi
Feb 27, 1995·Molecular and Cellular Endocrinology·C ChakrabortyH G Friesen
Sep 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·J E BourkeL Martin
Apr 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·J D CroxtallJ O White
Oct 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·M CorvolL Tsagris
Oct 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·B R Westley, F E May
Oct 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·L SahlinH Eriksson
Oct 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·L Sahlin
Jul 1, 1996·The Journal of Steroid Biochemistry and Molecular Biology·L Sahlin, H Eriksson
Mar 1, 1995·Trends in Endocrinology and Metabolism : TEM·L C Giudice, W Saleh
Jan 16, 1995·The American Journal of Medicine·R P Buyalos
Aug 27, 1994·Lancet·S M Ismail
Feb 7, 1998·Molecular and Cellular Endocrinology·R N RoyB R Bhavnani
Jan 1, 1997·Brain Research Bulletin·M C Fernandez-GalazL M Garcia-Segura

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.