Estrogen induces rapid translocation of estrogen receptor beta, but not estrogen receptor alpha, to the neuronal plasma membrane.

Neuroscience
L C SheldahlDaniel M Dorsa

Abstract

Estrogen receptors can activate transcription in the nucleus, and activate rapid signal transduction cascades in the cytosol. Multiple reports identify estrogen receptors at the plasma membrane, while others document the dynamic responses of estrogen receptor to ligand binding. However, the function and identity of membrane estrogen receptors remain controversial. We have used confocal microscopy and cell fractionation on the murine hippocampus-derived HT22 cell line and rat primary cortical neurons transfected with estrogen receptor-green fluorescent protein constructs to address the membrane localization of these receptors. We observe translocation of estrogen receptor beta (beta) to the plasma membrane 5 min after exposure to 17beta-estradiol, whereas estrogen receptor alpha (alpha) localization remains unchanged. Membrane localization of estrogen receptor beta is transient, selective for 17beta-estradiol, and is not blocked by ICI182,780. Inhibition of the mitogen-activated protein kinase pathway does not block estrogen-mediated estrogen receptor beta membrane translocation, and in fact prolongs membrane localization. These data suggest that while both estrogen receptor alpha and estrogen receptor beta can be present at the...Continue Reading

References

Jan 1, 1986·Journal of Steroid Biochemistry·S GreenP Chambon
Aug 30, 1994·Proceedings of the National Academy of Sciences of the United States of America·S M AronicaB S Katzenellenbogen
Dec 2, 1999·Neuroscience and Biobehavioral Reviews·P PalanzaF S vom Saal
Dec 10, 1999·The Journal of Endocrinology·J A Gustafsson
May 8, 2000·Journal of Neuroscience Research·K HondaS Shimohama
May 30, 2001·The Journal of Steroid Biochemistry and Molecular Biology·C E PowellC Sonnenschein
Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·N VasudevanD W Pfaff
Apr 19, 2002·Steroids·Cheryl S WatsonBahiru Gametchu
Dec 12, 2002·Steroids·Deborah A Lannigan
Mar 26, 2003·The Journal of Steroid Biochemistry and Molecular Biology·A MigliaccioF Auricchio
Aug 9, 2003·The Journal of Endocrinology·K TakahashiH Kurachi
Dec 13, 2003·Endocrinology·C Dominique Toran-Allerand
Feb 11, 2004·Endocrine Reviews·Carolyn L Smith, Bert W O'Malley
Feb 14, 2004·Molecular Endocrinology·Frank BarlettaBoris J Cheskis
Jul 3, 2004·Molecular Endocrinology·Mahnaz RazandiEllis R Levin
Jan 26, 2005·Hippocampus·Katarzyna KalitaLeszek Kaczmarek
Feb 8, 2005·Molecular Endocrinology·Linda Björnström, Maria Sjöberg
Feb 12, 2005·Science·Chetana M RevankarEric R Prossnitz
Mar 22, 2005·Journal of Cellular Biochemistry·Darlene C DeecherLawrence T O'Connor
Apr 16, 2005·Molecular Endocrinology·Deshanie RaiBenita S Katzenellenbogen
Oct 29, 2005·Steroids·Margaret Warner, Jan-Ake Gustafsson
Apr 29, 2006·Molecular Endocrinology·Ali PedramEllis R Levin
Jun 21, 2006·Endocrine·Damani N BryantDaniel M Dorsa
Mar 31, 2007·Endocrine-related Cancer·Paola GalluzzoMaria Marino
May 31, 2007·The Journal of Biological Chemistry·Ali PedramEllis R Levin
Sep 15, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marissa I BoulwarePaul G Mermelstein

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Citations

Jul 16, 2010·Cellular and Molecular Life Sciences : CMLS·Christopher M Stern, Paul G Mermelstein
Aug 6, 2009·International Journal of Colorectal Disease·Aisling M HoganDes C Winter
Jul 28, 2010·Behavioural Pharmacology·Sonali LokugeMeir Steiner
Apr 3, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Reymundo DominguezMichel Baudry
Aug 30, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stephanie M FernandezKaryn M Frick
Feb 11, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Quan-Gui GaoMan-Sau Wong
Jun 1, 2014·Frontiers in Neuroendocrinology·Ashley M Fortress, Karyn M Frick
Sep 18, 2012·Frontiers in Neuroendocrinology·Charlotte A CornilJacques Balthazart
Jul 26, 2012·Frontiers in Neuroendocrinology·Paul Micevych, Amy Christensen
Feb 23, 2010·Journal of Neuroscience Methods·Melissa A SnyderCatherine S Woolley
Nov 17, 2009·Biochimica Et Biophysica Acta·Karyn M FrickLauren L Harburger
Apr 30, 2015·Hormones and Behavior·Maria-Angeles ArevaloLuis M Garcia-Segura
May 12, 2015·Hormones and Behavior·Karyn M Frick
May 7, 2009·Frontiers in Neuroendocrinology·Paul Micevych, Reymundo Dominguez
Nov 11, 2011·Journal of Neuroendocrinology·R W IrwinR D Brinton
Sep 14, 2013·Journal of Neuroendocrinology·K M Frick
Jun 12, 2013·Journal of Neuroendocrinology·L Remage-HealeyN R Joshi
Apr 10, 2016·Cellular and Molecular Neurobiology·Javier MoránCelestino González
Mar 15, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Alessandra ColciagoFabio Celotti
May 12, 2009·Frontiers in Neuroendocrinology·Christian J PikeAnna M Barron
Jul 30, 2014·Journal of Leukocyte Biology·Andrea E SchneiderJanos Matko
Sep 21, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ying WangKeith P Choe
May 11, 2017·Journal of Neuroendocrinology·P A S SheppardE Choleris
Nov 11, 2009·Journal of Receptor and Signal Transduction Research·Volodymyr RybalchenkoPeter Koulen
Jan 9, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Shuhui ZhengXiaodong Fu
Aug 28, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Zeinab VahidiniaMohammad Taghi Joghataei
Apr 14, 2011·Science Signaling·Yuet-Kin Leung, Shuk-Mei Ho
Jun 19, 2014·Learning & Memory·Bronwyn M Graham, Mohammed R Milad

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