Estrogen maintains nitric oxide synthesis in arterioles of female hypertensive rats

Hypertension
An HuangAkos Koller

Abstract

We hypothesized that in female spontaneously hypertensive rats (SHR), estrogen moderates the dysfunction of arterioles by preserving nitric oxide synthesis. To this end, we conducted experiments on isolated gracilis muscle arterioles (approximately 55 microns in diameter) of 12-week-old (SHR divided into four groups: females (fSHR), ovariectomized females (fSHR-OV), ovariectomized females with estrogen replacement (fSHR-OV+ES, 50 micrograms/kg SC 17 beta-estradiol benzoate every 48 hours), and males (mSHR). Arteriolar diameter in the presence of perfusion pressures of 60, 80, 100, and 120 mm Hg were obtained, and diameter changes were measured (at 80 mm Hg) in response to various concentrations of substance P (10(-9) to 5 x 10(-8) mol/L), sodium nitroprusside (10(-8) to 10(-6) mol/L), and A23187 (5 x 10(-8) to 10(-6) mol/L). The pressure-induced diameter of mSHR and fSHR-OV arterioles was significantly less (by approximately 10%) than that of fSHR and fSHR-OV+ES arterioles. N omega-nitro-L-arginine (10(-4) mol/L), a nitric oxide synthase inhibitor, elicited a significant decrease in basal arteriolar diameter of fSHR (by approximately 19%) and fSHR-OV+ES (by approximately 17%), thereby eliminating the differences in tone among t...Continue Reading

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Citations

Feb 20, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·D EatmanM A Bayorh
Nov 6, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jennifer C SullivanJennifer S Pollock
Apr 29, 2014·European Heart Journal Supplements : Journal of the European Society of Cardiology·Akos Koller
Sep 25, 2003·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·R G V SmoldersP Kenemans
Jul 14, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H V CarswellI M Macrae
Oct 15, 2019·Medicine and Science in Sports and Exercise·Lasse GliemannYlva Hellsten
Feb 21, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Sukrutha VeerareddySandra T Davidge
Mar 27, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Ghezal FrooghAn Huang
Aug 19, 2003·Journal of Hypertension·Lisa BrandinHelena Gustafsson
Jun 17, 1998·The Journal of Prosthetic Dentistry·T T DaoV Ton-That
Aug 3, 2021·Clinical Science·Ahmed A Elmarakby, Jennifer C Sullivan

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