Estrogen-mediated protection against coronary heart disease: The role of the Notch pathway

The Journal of Steroid Biochemistry and Molecular Biology
Francesca FortiniP Rizzo

Abstract

Estrogen regulates a plethora of biological processes, under physiological and pathological conditions, by affecting key pathways involved in the regulation of cell proliferation, fate, survival and metabolism. The Notch receptors are mediators of communication between adjacent cells and are key determinants of cell fate during development and in postnatal life. Crosstalk between estrogen and the Notch pathway intervenes in many processes underlying the development and maintenance of the cardiovascular system. The identification of molecular mechanisms underlying the interaction between these types of endocrine and juxtacrine signaling are leading to a deeper understanding of physiological conditions regulated by these steroid hormones and, potentially, to novel therapeutic approaches to prevent pathologies linked to reduced levels of estrogen, such as coronary heart disease, and cardiotoxicity caused by hormone therapy for estrogen-receptor-positive breast cancer.

Citations

Jul 16, 2019·Expert Opinion on Therapeutic Targets·Giorgio AquilaAnna Malaschicheva
Apr 11, 2020·Basic Research in Cardiology·Paola RizzoRoberto Ferrari
Aug 5, 2020·Journal of Clinical Medicine·Veronica PapaFrancesco Vieceli Dalla Sega
Jun 14, 2019·Frontiers in Immunology·Francesco Vieceli Dalla SegaPaola Rizzo
Oct 9, 2019·International Journal of Molecular Sciences·Francesco Vieceli Dalla SegaSaverio Francesco Retta
Sep 20, 2020·International Journal of Molecular Sciences·Arun Samidurai, Anindita Das
Aug 28, 2021·Biomedicines·Francesca FortiniRoberto Ferrari

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