Estrogen-metabolizing gene polymorphisms in the assessment of breast carcinoma risk and fibroadenoma risk in Caucasian women

Cancer
Lukas A HeflerHeinz Koelbl

Abstract

Genes encoding enzymes involved in estrogen metabolism are held to be candidate genes for associations with breast disease. In these candidate genes, no critical combination of single-nucleotide polymorphisms (SNPs) for assessing breast carcinoma risk has been reported to date. In a large case-control study, the authors investigated 10 estrogen-metabolizing SNPs in 396 patients with breast carcinoma, 154 patients with fibroadenoma, and 1936 healthy control patients without breast carcinoma in their personal history. The following 10 SNPs were analyzed using sequencing-on-chip technology via a solid-phase polymerase chain reaction assay performed on oligonucleotide microarrays: catechol-O-methyltransferase Val158Met G-->A, 17-beta-hydroxysteroid dehydrogenase type 1 vIV A-->C, cytochrome P-450 (CYP) family 17 A2 allele T-->C, CYP1A1-1 MspI restriction fragment length polymorphism (RFLP) T-->C, CYP1A1-2 Ile462Val A-->G, CYP19-1 Trp39Arg T-->C, CYP19-2 Arg264Cys C-->T, CYP19-3 Cys1558Thr C-->T, steroid-5-alpha reductase type 2 Val89Leu G-->C, and vitamin D receptor BsmI RFLP. A total of 21,350 genotypes were evaluated. Associations and two-way interaction models were calculated using stepwise logistic regression. In a multiple mod...Continue Reading

References

Feb 19, 1992·JAMA : the Journal of the American Medical Association·S J LondonG A Colditz
Mar 17, 1997·International Journal of Cancer. Journal International Du Cancer·J R PasqualiniA Ruiz
Mar 28, 1998·Science·R F Service
Mar 14, 2000·Oncogene·V N KristensenA L Børresen-Dale
Sep 15, 2001·British Journal of Cancer·M Bergman-Jungeström, S Wingren
Nov 8, 2001·Carcinogenesis·V M BashamA M Dunning
Jul 9, 2002·The Breast Journal·Yasuo MiyoshiShinzaburo Noguchi
Aug 15, 2002·Cancer Letters·Lídia da Fonte de AmorimLuis Pinto
Jan 3, 2003·The New England Journal of Medicine·Muin J KhouryEdward R B McCabe
Feb 27, 2003·Breast Cancer Research and Treatment·Christopher A HaimanCelia Byrne
Jul 9, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Aron GoldhirschHans-Jörg Senn

❮ Previous
Next ❯

Citations

Mar 16, 2006·Breast Cancer Research and Treatment·Lukas A HeflerRobert Zeillinger
Jun 30, 2006·Breast Cancer Research and Treatment·Virendra SinghMahendra Pratap Singh
Oct 26, 2006·Breast Cancer Research and Treatment·Pia SillanpääAri Hirvonen
Jan 16, 2009·Breast Cancer Research and Treatment·Chunbo TangYifei Du
Dec 26, 2009·Breast Cancer Research and Treatment·Theodoros N Sergentanis, Konstantinos P Economopoulos
Aug 1, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jie WangWei Bao
Apr 13, 2006·Rejuvenation Research·Elizabeth H Corder, Lukas A Hefler
Dec 10, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Chu ChenDavid B Thomas
Nov 11, 2005·Breast Cancer Research : BCR·Kristjana EinarsdóttirSara Wedrén
May 21, 2010·The Journal of Nutrition·Zakia Coriaty NelsonDavid B Thomas
Jul 30, 2014·Cell Biochemistry and Biophysics·Xiaorui LiXiaochun Kang
Dec 2, 2005·Obstetrics and Gynecology·Kala VisvanathanJodi A Flaws
Dec 20, 2007·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Pavol ZuborJan Danko
Jul 13, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Clemens B TempferJohannes C Huber
Jun 12, 2009·Drug Metabolism Reviews·Shu-Feng ZhouBalram Chowbay
Oct 25, 2011·Cancer Epidemiology·Randa G NaffaSaid I Ismail
Nov 26, 2008·Molecular and Cellular Endocrinology·Gabriele Moeller, Jerzy Adamski
Dec 18, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Marie PlourdeUNKNOWN INHERIT BRCAs
Mar 30, 2010·International Journal of Andrology·W KristiansenE L Aschim
Sep 5, 2006·The American Journal of Medicine·Carolyn J CrandallEllen B Gold
Feb 27, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Qian-Qian HuangSi-Dong Chen
Apr 17, 2015·Journal of Evidence-based Complementary & Alternative Medicine·Mark LucockMartin Veysey
Oct 27, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Mehir Un Nisa Iqbal, Taseer Ahmed Khan
Mar 24, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Anna SapinoGianni Bussolati
Feb 7, 2012·Genetic Testing and Molecular Biomarkers·Yousra SouidenKacem Mahdouani

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.