Estrogen Modulates the Sensitivity of Lung Vagal C Fibers in Female Rats Exposed to Intermittent Hypoxia

Frontiers in Physiology
Ya-Chen HuangChing Jung Lai

Abstract

Obstructive sleep apnea is mainly characterized by intermittent hypoxia (IH), which is associated with hyperreactive airway diseases and lung inflammation. Sensitization of lung vagal C fibers (LVCFs) induced by inflammatory mediators may play a central role in the pathogenesis of airway hypersensitivity. In females, estrogen interferes with inflammatory signaling pathways that may modulate airway hyperreactivity. In this study, we investigated the effects of IH on the reflex and afferent responses of LVCFs to chemical stimulants and lung inflammation in adult female rats, as well as the role of estrogen in these responses. Intact and ovariectomized (OVX) female rats were exposed to room air (RA) or IH for 14 consecutive days. On day 15, IH enhanced apneic responses to right atrial injection of chemical stimulants of LVCFs (e.g., capsaicin, phenylbiguanide, and α,β-methylene-ATP) in intact anesthetized females. Rats subjected to OVX prior to IH exposure exhibited an augmented apneic response to the same dose of stimulants compared with rats subjected to other treatments. Apneic responses to the stimulants were completely abrogated by bilateral vagotomy or perivagal capsaicin treatment, which blocked the neural conduction of LVC...Continue Reading

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Citations

Jul 17, 2019·Sleep & Breathing = Schlaf & Atmung·Lixiu ZhangXiaohong Lv
Jun 25, 2020·American Journal of Perinatology·V Peter NagrajKaren D Fairchild

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Methods Mentioned

BETA
Bronchoalveolar Lavage
enzyme-linked immunosorbent assay
ELISA
X-ray
MDA
bronchoalveolar
lavage

Software Mentioned

BioCybernatics
ImageJ

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