Estrogen negative feedback on gonadotropin secretion: evidence for a direct pituitary effect in women.

The Journal of Clinical Endocrinology and Metabolism
N D ShawJ E Hall

Abstract

Studies in humans and animals indicate that estrogen negative feedback occurs at the level of the hypothalamus, but it is unclear whether estrogen also exerts an inhibitory effect directly at the pituitary. The aim of the study was to determine whether estrogen has a direct negative feedback effect at the pituitary and whether this varies with aging. A GnRH antagonist and graded doses of GnRH were used to isolate pituitary responsiveness before and after estrogen administration in Clinical Research Center studies at an academic medical center. Subjects were healthy postmenopausal women aged 48-56 yr (n = 8) or 70-75 yr (n= 8). A suppressive dose of the NAL-GLU GnRH antagonist was administered, followed by graded doses of GnRH before and after 1 month of estrogen administration. LH and FSH responses to GnRH decreased after estrogen administration (P = 0.01 and P = 0.0001, respectively). The ratio of FSH to LH amplitudes decreased in response to estrogen (P = 0.04) indicating a greater sensitivity of FSH than LH to inhibition by estrogen. The inhibitory effect of estrogen on FSH was attenuated with aging (P = 0.02), but was maintained for LH (P = 0.4). Studies that control for endogenous GnRH and estradiol demonstrate a direct pi...Continue Reading

Associated Clinical Trials

Oct 11, 2006·Janet E. Hall, MD, Janet E. Hall, MD

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Citations

May 12, 2011·American Journal of Physiology. Endocrinology and Metabolism·N D ShawJ E Hall
Jan 24, 2013·Molecular Endocrinology·Stella TranDaniel J Bernard
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Jun 25, 2017·Environmental Toxicology·Masumeh MirzaeiRajabali Sadrkhanlou

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