Estrogen, NFkappaB, and the heat shock response.

Molecular Medicine
James P Stice, Anne A Knowlton

Abstract

Estrogen has pleiotropic actions, among which are its anti-apoptotic, anti-inflammatory, and vasodilatory effects. Recently, an interaction between 17beta-estradiol (E2) and the transcription factor nuclear factor kappaB (NFkappaB) has been identified. NFkappaB has a central role in the control of genes involved in inflammation, proliferation, and apoptosis. Prolonged activation of NFkappaB is associated with numerous inflammatory pathological conditions. An important facet of E2 is its ability to modulate activity of NFkappaB via both genomic and nongenomic actions. E2 can activate NFkappaB rapidly via nongenomic pathways, increase cellular resistance to injury, and induce expression of the protective class of proteins, heat shock proteins (HSPs). HSPs can bind to many of the pro-apoptotic and pro-inflammatory targets of NFkappaB and, thus, indirectly inhibit many of its deleterious effects. In addition, HSPs can block NFkappaB activation and binding directly. Similarly, genomic E2 signaling can inhibit NFkappaB, but does so through alternative mechanisms. This review focuses on the molecular mechanisms of cross-talk between E2, NFkappaB, and HSPs, and the biological relevance of this cross-talk.

References

May 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·X YangG Shyamala
Jun 1, 1995·American Heart Journal·K PrzyklenkR A Kloner
Jan 1, 1996·Annual Review of Immunology·A S Baldwin
Jul 25, 1997·The Journal of Biological Chemistry·B Segnitz, U Gehring
Jun 11, 1999·The New England Journal of Medicine·M E Mendelsohn, R H Karas
May 10, 2000·The Journal of Biological Chemistry·M P Pando, I M Verma
Sep 12, 2000·Nature Cell Biology·J M BrueyC Garrido
Sep 20, 2000·American Journal of Physiology. Heart and Circulatory Physiology·D JarrarI H Chaudry
Sep 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·S SatoT Tsuruo
Oct 6, 2000·Journal of the National Cancer Institute·C Jolly, R I Morimoto
Dec 21, 2000·American Journal of Physiology. Heart and Circulatory Physiology·A A Knowlton, L Sun
May 10, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·L PirkkalaL Sistonen
Aug 14, 2001·Journal of Cellular Biochemistry·Y ZhangN F Mivechi
Oct 27, 2001·Circulation Research·M J EvansD C Harnish
Jan 10, 2002·Critical Care Medicine·Elisabeth S ChristiansIvor J Benjamin
Jan 15, 2002·American Journal of Physiology. Cell Physiology·Zain ParooEarl G Noble
Mar 5, 2002·Nature Immunology·Michael Karin, Anning Lin
May 2, 2002·Cell·Sankar Ghosh, Michael Karin
Jun 19, 2002·Circulation·S R KirchhoffA A Knowlton
Aug 21, 2002·JAMA : the Journal of the American Medical Association·Heidi D NelsonJanet D Allan
Apr 26, 2003·American Journal of Physiology. Heart and Circulatory Physiology·M R VossA A Knowlton
Aug 21, 2003·Lancet·Valerie Beral, UNKNOWN Million Women Study Collaborators

❮ Previous
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Citations

Aug 23, 2008·Cell Stress & Chaperones·Philip L Hooper, Paul L Hooper
Dec 17, 2009·Cell Stress & Chaperones·Esma Ucisik-AkkayaM Tevfik Dorak
Feb 14, 2012·Cell Stress & Chaperones·Elena DulinMaria C Guisasola
Dec 31, 2010·Shock·Samuel KobbaAnne A Knowlton
Apr 18, 2009·Future Cardiology·James P SticeAnne A Knowlton
Nov 18, 2014·Mediators of Inflammation·Rosário MonteiroConceição Calhau
Jan 22, 2010·Women's Health·Poornima BhupathyLeslie Anne Leinwand
Dec 16, 2016·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Katarzyna SzoltysekPiotr Widlak
Nov 5, 2017·Cell Stress & Chaperones·Maria Concepción GuisasolaFrancisco Chana
Apr 7, 2016·The Journal of Endocrinology·Yuriko Kitajima, Yusuke Ono
Dec 1, 2018·American Journal of Physiology. Heart and Circulatory Physiology·HyunTae V HwangAnne A Knowlton
Aug 6, 2009·Archives of Gynecology and Obstetrics·Levent KebapcilarIsmail Sari
Feb 9, 2010·Cellular and Molecular Life Sciences : CMLS·Mónika AdoriGabriella Sármay
Feb 13, 2019·Endocrinology·Sean W Fanning, Geoffrey L Greene
Feb 21, 2014·The Journal of Clinical Endocrinology and Metabolism·Shee-Uan ChenJehn-Hsiahn Yang
Mar 23, 2017·Endocrinology·Deborah CleggVictoria J Vieira-Potter
Apr 10, 2010·American Journal of Respiratory and Critical Care Medicine·Sanjay H ChotirmallNoel G McElvaney
Jun 6, 2015·Molecular and Cellular Biochemistry·Antônio Azambuja MiragemPaulo Ivo Homem de Bittencourt
Mar 27, 2019·Journal of Cellular Physiology·Chuanfeng TangLiang Sheng
Mar 18, 2015·Hormone Molecular Biology and Clinical Investigation·Valentina VicennatiRenato Pasquali
Nov 15, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hui TianJunNian Zheng
May 8, 2020·Oxidative Medicine and Cellular Longevity·Pablo Delgado-WickeSalvador González
Jul 31, 2012·Molecular Medicine Reports·Ya-Juan ZhaoHaginoya Kazuhiro
Apr 25, 2018·Temperature : Multidisciplinary Biomedical Journal·Brett R ElyChristopher T Minson
Feb 15, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tracey L PapenfussCaroline C Whitacre
Dec 29, 2020·Frontiers in Endocrinology·Fuqiong ChenJiarong Tang
Jun 11, 2021·Research in Veterinary Science·Sayed Haidar Abbas RazaLinsen Zan
Dec 1, 2009·Journal of Molecular and Cellular Cardiology·Y WangA A Knowlton
Aug 16, 2011·Molecular and Cellular Endocrinology·Ann E Drummond, Peter J Fuller

❮ Previous
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