Estrogen rapidly induces the phosphorylation of the cAMP response element binding protein in rat brain

Endocrinology
Y ZhouD M Dorsa

Abstract

Estrogen treatment of ovariectomized rats rapidly increases immunoreactivity for the phosphorylated form of the cAMP response element binding protein (CREB)in neurons of the preoptic area and the bed nucleus of the stria terminalis. These effects were detected within 15 minutes after estrogen exposure. Since the antisera used for these studies detect CREB phosphorylation at ser133, which is important for transcriptional activation these data provide a possible explanation for estrogen's effects on neuronal genes lacking estrogen response elements (EREs) but which contain cAMP response elements (CREs). These data also provide evidence for non-genomic effects of steroid hormones involving protein kinase associated signal transduction pathways traditionally associated with effects at the cell membrane.

Citations

Feb 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·D B DubalP M Wise
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·S C Papasozomenos
Apr 18, 2009·Harvard Review of Psychiatry·Veronica HarshPeter J Schmidt
Mar 25, 2010·Neuroendocrinology·Paul MicevychJohn Kuo
Jan 20, 2011·The Journal of Clinical Investigation·Cheryl J ParkJon E Levine
Aug 16, 2012·Endocrinology·Zahara AlimUlrich Boehm
Jul 19, 2008·Anesthesia and Analgesia·Kamila VagnerovaPatricia D Hurn
May 1, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zhiguo ChuSuzanne M Moenter
Aug 31, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Phoebe DewingPaul Micevych
Nov 2, 2004·Pflügers Archiv : European journal of physiology·Angel NadalEsther Fuentes
Aug 9, 2012·Frontiers in Neuroendocrinology·Martin J Kelly, Oline K Rønnekleiv
May 5, 2009·Frontiers in Neuroendocrinology·James W SimpkinsShao-Hua Yang
Jun 10, 2008·Molecular and Cellular Endocrinology·Martin J Kelly, Oline K Rønnekleiv
Nov 13, 2009·Annals of the New York Academy of Sciences·Peter J Schmidt, David R Rubinow
Mar 3, 2004·Annals of the New York Academy of Sciences·H F CarrerS Gorosito
Jun 3, 2017·Biochemical Pharmacology·Christine Heberden
Nov 11, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D B DubalP M Wise
Mar 11, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Anika M S HartzBjörn Bauer
Dec 18, 2001·Journal of Neuroscience Research·M J Cambiasso, H F Carrer
Oct 9, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Karen HorsburghHilary Carswell
Mar 3, 2004·Annals of the New York Academy of Sciences·Martin J KellyOline K Rønnekleiv
Dec 23, 2015·Genetics & Epigenetics·Kazushi Inoue, Elizabeth A Fry
Sep 18, 2003·Journal of Neuroscience Research·Yun XuMichael M Wang
Sep 5, 1996·Nature·R Janknecht, T Hunter
Feb 22, 2005·Journal of Neuroscience Research·Myreille D'AstousThérèse Di Paolo
Jul 8, 2008·Journal of Neuroendocrinology·M M McCarthyS L Dean
Jul 26, 2008·Journal of Neuroscience Research·Lu FanRochelle S Cohen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.