Estrogen receptor-α is localized to neurofibrillary tangles in Alzheimer's disease.

Scientific Reports
Chunyu WangXiongwei Zhu

Abstract

The female predominance for developing Alzheimer disease (AD) suggests the involvement of gender specific factor(s) such as a reduced estrogen-estrogen receptor signaling in the pathogenesis of AD. The potential role of ERα in AD pathogenesis has been explored by several groups with mixed results. We revisited this issue of expression and distribution of ERα in AD brain using a specific ERα antibody. Interestingly, we found that ERα co-localized with neurofibrillary pathology in AD brain and further demonstrated that ERα interacts with tau protein in vivo. Immunoprecipitaion experiments found increased ERα-tau interaction in the AD cases, which may account for ERα being sequestered in neuronal tau pathology. Indeed, tau overexpression in M17 cells leads to interruption of estrogen signaling. Our data support the idea that sequestration of ERα by tau pathology underlies the loss of estrogen neuroprotection during the course of AD.

References

Feb 1, 1996·Biology of Reproduction·B S Katzenellenbogen
Aug 8, 1997·Cell·T Perlmann, R M Evans
Jul 1, 1997·Neurobiology of Aging·W R Markesbery
Jul 27, 1999·The Journal of Steroid Biochemistry and Molecular Biology·S M Cowley, M G Parker
Jul 11, 2001·Neurobiology of Aging·A RuitenbergM M Breteler
Apr 17, 2002·Biological Psychiatry·Kristine YaffePhilip Morin
Oct 22, 2002·American Journal of Physiology. Endocrinology and Metabolism·Chris StironeDiana N Krause
Oct 2, 2003·Brain Research. Developmental Brain Research·Sylvia E PérezElliott J Mufson
Dec 24, 2004·Biochimica Et Biophysica Acta·Lester I BinderRobert W Berry
Jun 9, 2005·Archives of General Psychiatry·Lisa L BarnesDavid A Bennett
Mar 16, 2006·Psychiatric Genetics·Line OlsenThomas Werge
Oct 3, 2006·Neurobiology of Aging·Tatjana A IshuninaDick F Swaab
May 18, 2007·Neurobiology of Learning and Memory·Cheryl A FryeAlicia A Walf
Mar 14, 2008·Neurochemical Research·Xin-An LiuJian-Zhi Wang
Jun 11, 2008·Molecular and Cellular Endocrinology·Yasushi HojoSuguru Kawato
Aug 22, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Quan-Guang ZhangDarrell W Brann
Nov 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Quan-Guang ZhangDarrell W Brann
Jan 27, 2010·Biochimica Et Biophysica Acta·Jill M Daniel, Johannes Bohacek
Feb 20, 2010·Current Aging Science·Sónia C CorreiaPaula I Moreira
Apr 27, 2010·Neurobiology of Aging·Tatjana A Ishunina, Dick F Swaab

❮ Previous
Next ❯

Citations

Jun 18, 2016·Frontiers in Cellular Neuroscience·Michela GuglielmottoSantina Cutrupi
May 26, 2018·JAMA Neurology·Timothy J HohmanUNKNOWN Alzheimer’s Disease Genetics Consortium and the Alzheimer’s Disease Neuroimaging Initiative
Apr 15, 2018·The Journal of Endocrinology·Ángel Enrique Céspedes RubioFrancisco Wandosell
Jun 11, 2020·Psychiatry Investigation·Yoo Hyun Um, Hyun Kook Lim
Apr 15, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Tobore Onojighofia Tobore
Feb 19, 2019·Journal of Alzheimer's Disease : JAD·Tobore Onojighofia Tobore
Mar 5, 2021·Reviews in the Neurosciences·Harish IyerArvind Kumar
Apr 1, 2018·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Reymundo DominguezWilliam J Mack
Sep 7, 2020·Mechanisms of Ageing and Development·Ioanna Daskalaki, Nektarios Tavernarakis
Oct 9, 2021·Essays in Biochemistry·Silvia MaioliIvan Nalvarte

❮ Previous
Next ❯

Methods Mentioned

BETA
immunoprecipitation
dot-blot
co-immunoprecipitation
transfection
dot blot
electrophoresis
dot blots
Assay

Software Mentioned

Image J
SPSS

Related Concepts

Related Feeds

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.