PMID: 16612467Apr 14, 2006Paper

Estrogen receptor 1 gene polymorphisms and coronary artery disease in the Brazilian population

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
S Almeida, M H Hutz

Abstract

We examined the association of three established single nucleotide polymorphisms, IVS1-397T>C, IVS1-351A>G, and +261G>C, in the ESR1 gene with the prevalence and severity of coronary atherosclerosis in a southern Brazilian population of European ancestry. Three hundred and forty-one subjects (127 women and 214 men) with coronary artery disease (CAD) were classified as having significant disease (CAD+ patient group) when they showed 60% or more luminal stenosis in at least one coronary artery or major branch segment at angiography; patients with 10% or less luminal stenosis were considered to have minimal CAD (CAD- patient group). The control sample consisted of 142 subjects (79 women and 63 men) without significant disease, in whom coronary angiography to rule out the presence of asymptomatic CAD was not performed. The polymorphisms were investigated by polymerase chain reaction followed by restriction analyses. In the male sample, the +261G>C*C allele was more frequent in CAD+ than CAD- subjects (8 versus 1%, P = 0.024). Homozygosity for the C allele of the IVS1-397T>C polymorphism was also significantly associated with increased CAD severity (OR: 2.99; 95% CI = 1.35-6.63; P = 0.007). In agreement with previous findings, these...Continue Reading

References

Oct 21, 1991·Nucleic Acids Research·D K Lahiri, J I Nurnberger
Nov 1, 1988·Genetics·R C Lewontin
Dec 1, 1994·Human Genetics·T I AndersenA L Børresen
Apr 1, 1993·Hypertension·S LehrerB S Schachter
Mar 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S KobayashiH Orimo
Jan 28, 1999·Biochemical and Biophysical Research Communications·S F Ofori-AcquahD M Layton
Jun 11, 1999·The New England Journal of Medicine·M E Mendelsohn, R H Karas
Oct 6, 1999·Genome Research·R J PetersonJ C Long
Nov 30, 2000·Biochemical and Biophysical Research Communications·C OhlssonJ A Gustafsson
Mar 15, 2002·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Terho LehtimäkiPekka J Karhunen
Jun 13, 2002·European Journal of Clinical Investigation·T LehtimäkiJ Knuuti
Oct 18, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Valeria FerreroWilliam Wijns
Oct 29, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Domingos L S RiosMara H Hutz
Nov 6, 2003·JAMA : the Journal of the American Medical Association·Amanda M ShearmanDaniel Levy
Nov 6, 2003·JAMA : the Journal of the American Medical Association·Paul N Hopkins, Eliot A Brinton
Mar 17, 2004·Menopause : the Journal of the North American Menopause Society·Angela H E M MaasYolanda van der Graaf
Jun 24, 2004·JAMA : the Journal of the American Medical Association·Stephanie C E SchuitAndré G Uitterlinden
Jun 24, 2004·JAMA : the Journal of the American Medical Association·Christopher Newton-Cheh, Christopher J O'Donnell
Nov 2, 2004·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Tarja A KunnasSeppo T Nikkari
Dec 21, 2004·Epidemiologic Perspectives & Innovations : EP+I·Joseph H Abramson

❮ Previous
Next ❯

Citations

Jan 11, 2007·Breast Cancer Research and Treatment·Sonal Gandhi, Sunil Verma
Apr 28, 2010·The American Journal of the Medical Sciences·Larissa P AlcazarMaria Santos
Nov 15, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Jolanta MyśliwskaDominik Rachoń
Mar 7, 2014·Journal of Zhejiang University. Science. B·Jie DingXiao-gang Guo
Jun 28, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Haiying XuYunfeng Han
Nov 26, 2008·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·S Almeida, M H Hutz
Jun 10, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Lisiane SmiderleSilvana Almeida
Jun 19, 2014·Experimental and Therapeutic Medicine·Huan ZhangFeng Ma

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.