Estrogen receptor 2 and progesterone receptor gene polymorphisms and lipid levels in women with different hormonal status

The Pharmacogenomics Journal
S AlmeidaM H Hutz

Abstract

Sex steroid hormones have multiple effects on lipid metabolism. We investigated the association between two common single nucleotide polymorphisms of the estrogen receptor 2 gene (ESR2), 1082G>A and 1730A>G, and PROGINS polymorphism of the progesterone receptor gene (PGR) with lipoprotein levels in a cross-sectional study with 472 women of European descent. The women were classified into three subgroups according to hormonal status, premenopausal women (n=187; mean age=34+/-9.7 years), postmenopausal women exposed to hormone replacement therapy (HRT) (n=118; 56+/-6.7 years) and postmenopausal women unexposed to HRT (n=167; 58+/-9.8 years). The premenopausal and postmenopausal women exposed to HRT, both carriers of G/A genotype, exhibited LDL-C (P=0.027 and 0.001, respectively) and T-chol levels (P=0.035 and 0.001, respectively) lower than carriers of G/G genotype. This association was not observed in postmenopausal women unexposed to HRT. These results suggest that ESR2 1082G>A genotype may influence LDL-C levels in women with abundant estrogen levels, due to either endogenous or exogenous sources.

References

Oct 21, 1991·Nucleic Acids Research·D K Lahiri, J I Nurnberger
Nov 1, 1987·Human Genetics·M F Rousseau-MerckR Berger
Nov 16, 1993·Biochimica Et Biophysica Acta·M MisrahiE Milgrom
Nov 5, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·P PariniM Rudling
Dec 17, 1997·The Journal of Clinical Endocrinology and Metabolism·E EnmarkJ A Gustafsson
Jul 15, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·P PariniM Rudling
Jan 4, 2001·Computer Methods and Programs in Biomedicine·A Alioum, D Commenges
Jun 19, 2001·Neuroscience Letters·J C LambertC Lendon
Mar 8, 2002·Atherosclerosis·Denise von MuhlenDonna Kritz-Silverstein
Mar 13, 2002·Ambulatory Pediatrics : the Official Journal of the Ambulatory Pediatric Association·R KarpJ Deutsch
Mar 15, 2002·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Terho LehtimäkiPekka J Karhunen
Jul 19, 2002·JAMA : the Journal of the American Medical Association·Jacques E RossouwUNKNOWN Writing Group for the Women's Health Initiative Investigators
Jan 14, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Lewis H Kuller, UNKNOWN Women's Health Initiative
Apr 15, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Dimitrios EvangelopoulosParaskevi Moutsatsou
Apr 30, 2003·Pharmacogenomics·David M Herrington, Tim D Howard
Jul 16, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Riikka MäkeläTerho Lehtimäki
Oct 18, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Valeria FerreroWilliam Wijns

❮ Previous
Next ❯

Citations

Oct 23, 2008·Genetic Testing·Seppo T NikkariTerho Lehtimäki
Nov 27, 2008·Metabolic Syndrome and Related Disorders·Alessandra C GoulartKathryn M Rexrode
May 30, 2006·Journal of Clinical Pathology·Hanna GränsBirgitta Evengård
Mar 3, 2006·The Journal of Clinical Investigation·Bonnie J Deroo, Kenneth S Korach
Dec 21, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Jiawei XinLi Xiong
Feb 14, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Lisiane SmiderleSilvana Almeida
Jun 10, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Lisiane SmiderleSilvana Almeida
Jun 28, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Haiying XuYunfeng Han
Jul 17, 2008·Biochemical and Biophysical Research Communications·Chikari TakeoMasaaki Muramatsu
Aug 18, 2006·Molecular Aspects of Medicine·Paolo AscenziMaria Marino
Feb 11, 2015·Metabolism: Clinical and Experimental·Zoe A EfstathiadouGeorge N Koukoulis
Aug 24, 2007·Clinical Pharmacology and Therapeutics·N I NtukidemUNKNOWN Consortium on Breast Cancer Pharmacogenomics
Jan 19, 2010·The Journal of Clinical Endocrinology and Metabolism·Aris BechlioulisLampros K Michalis
May 22, 2007·Journal of Gerontological Nursing·Donna J Plonczynski, Katrina J Plonczynski

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.