Estrogen receptor alpha and risk for cognitive impairment in postmenopausal women

Psychiatric Genetics
Line OlsenThomas Werge

Abstract

The estrogen receptor alpha (ESR1) gene has been implicated in the process of cognitive impairment in elderly women. In a paired case-control study, we tested whether two ESR1 gene polymorphisms (the XbaI and PvuII sites) are risk factors for cognitive impairment as measured by the six-item Orientation-Memory-Concentration test in postmenopausal Danish women. Hormone replacement therapy, age and executive cognitive ability were examined as covariates for ESR1 gene effects on cognitive impairment. The XbaI polymorphism showed a marginal effect on cognitive abilities (P=0.054) when adjusted for executive cognitive ability. Using a dominant genetic model for the X allele, we found an elevated risk (executive cognitive ability adjusted P=0.033) for cognitive impairment. Hormone replacement therapy also had a borderline effect on cognitive ability (P=0.049) and this effect was reflected in executive cognitive ability. These data support that the ESR1 gene variants affect cognitive functioning in postmenopausal women.

References

Oct 1, 1973·The British Journal of Psychiatry : the Journal of Mental Science·B Isaacs, A T Kennie
Jun 1, 1983·The American Journal of Psychiatry·R KatzmanH Schimmel
Nov 24, 1999·Biochemical and Biophysical Research Communications·M L BrandiS Govoni
Apr 20, 2001·The New England Journal of Medicine·K YaffeUNKNOWN Multiple Outcomes of Raloxifene Evaluation Investigators
Apr 17, 2002·Biological Psychiatry·Kristine YaffePhilip Morin
Oct 4, 2002·Maturitas·Andrea R GenazzaniMarco Gambacciani
May 10, 2003·Neurochemical Research·Sam Gandy
Nov 25, 2003·Journal of Neuroscience Research·Robert B Gibbs, Rachel Gabor
Jul 21, 2004·Molecular Psychiatry·T den HeijerM M B Breteler

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Citations

Dec 13, 2007·International Psychogeriatrics·Joanne RyanMarie-Laure Ancelin
Jul 3, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Thomas C FosterSusan L Semple-Rowland
Jul 10, 2010·Menopause : the Journal of the North American Menopause Society·Erin E SundermannJeffrey R Bishop
Feb 9, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xiaoxia HanThomas C Foster
Feb 4, 2016·Scientific Reports·Chunyu WangXiongwei Zhu
Mar 18, 2008·Neuroscience Letters·Marina BoccardiGiovanni B Frisoni
Oct 5, 2010·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Sandeep GroverRitushree Kukreti
Aug 3, 2010·Neurobiology of Aging·Mercé BoadaJosé Jorge Galán
Aug 13, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Joanne RyanMarie-Laure Ancelin
Nov 7, 2012·Neuropsychobiology·Chad A BousmanIan P Everall
Sep 25, 2017·Journal of Neuroendocrinology·S J OwensC Shannon Weickert
Feb 11, 2014·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Linda A BeanThomas C Foster
Dec 14, 2018·Brain Sciences·Mayra Gutiérrez-MuñozSilvia Solís-Ortiz
Sep 30, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Iwona BojarMariusz Gujski
Jul 15, 2017·Frontiers in Neuroendocrinology·Donna L Maney
Oct 9, 2021·Essays in Biochemistry·Silvia MaioliIvan Nalvarte

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