Estrogen receptor-alpha deficiency attenuates autoimmune disease in (NZB x NZW)F1 mice

Genes and Immunity
K K BynotéKaren A Gould

Abstract

Estrogens promote lupus in humans and some mouse models of this disease. Nonetheless, little is known about the role of estrogen receptors in lupus pathogenesis. Here, we report that in females on the lupus-prone (NZB x NZW)F(1) background, disruption of estrogen receptor-alpha (ER alpha or Esr1) attenuated glomerulonephritis and increased survival. ER alpha deficiency also retarded development of anti-histone/DNA antibodies, suggesting that ER alpha promotes loss of immunologic tolerance. Furthermore, ER alpha deficiency in (NZB x NZW)F(1) females attenuated the subsequent development of anti-double-stranded DNA (dsDNA) IgG antibodies, which are associated with glomerulonephritis in this model. We provide evidence that ER alpha may promote lupus, at least in part, by inducing interferon-gamma, an estrogen-regulated cytokine that impacts this disease. ER alpha deficiency in (NZB x NZW)F(1) males increased survival and reduced anti-dsDNA antibodies, suggesting that ER alpha also modulates lupus in males. These studies demonstrate that ER alpha, rather than ER beta, plays a major role in regulating autoimmunity in (NZB x NZW)F(1) mice. Furthermore, our results suggest for the first time that ER alpha promotes lupus, at least in p...Continue Reading

References

Nov 1, 1978·The Journal of Experimental Medicine·B S AndrewsF J Dixon
May 1, 1979·The Journal of Clinical Investigation·J R RoubinianP K Siiteri
Nov 1, 1979·Arthritis and Rheumatism·R G LahitaJ Fishman
Dec 5, 1990·Journal of Immunological Methods·R W Burlingame, R L Rubin
Mar 1, 1968·The Journal of Experimental Medicine·P H Lambert, F J Dixon
Jan 1, 1968·Advances in Immunology·J B Howie, B J Helyer
Jul 1, 1981·The Journal of Clinical Endocrinology and Metabolism·R G LahitaJ Fishman
Mar 15, 1995·Annals of Internal Medicine·J Sánchez-GuerreroG A Colditz
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·D H KonoA N Theofilopoulos
Jul 1, 1994·The Journal of Clinical Investigation·R W BurlingameR L Rubin
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·C G DrakeB L Kotzin
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D B LubahnO Smithies
Apr 1, 1993·The Journal of Clinical Investigation·R W BurlingameA N Theofilopoulos
May 1, 1993·The Journal of Experimental Medicine·C MohanS K Datta
Feb 1, 1996·British Journal of Rheumatology·G Ruiz-IrastorzaN M Buchanan
Dec 24, 1996·Proceedings of the National Academy of Sciences of the United States of America·S J RozzoB L Kotzin
Dec 1, 1996·Journal of Autoimmunity·K KramersJ H Berden
May 1, 1997·Arthritis and Rheumatism·J Sanchez-GuerreroG A Colditz
Jan 29, 1999·Mammalian Genome : Official Journal of the International Mammalian Genome Society·L MorelE K Wakeland
Jun 22, 1999·The Journal of Clinical Investigation·C MohanE K Wakeland
Jul 23, 1999·Annals of the New York Academy of Sciences·M Ostensen
Mar 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·M S BynoeB Diamond
Sep 30, 2000·Scandinavian Journal of Immunology·W M WuB L Chiang
Feb 13, 2001·European Journal of Clinical Investigation·E N KassiP Moutsatsou
Jun 19, 2001·Seminars in Arthritis and Rheumatism·C C MokR W Wong
Jan 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Gil-Jin ShimJan-Ake Gustafsson
Apr 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chun XieChandra Mohan
Jul 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elena PeevaBetty Diamond

❮ Previous
Next ❯

Citations

Feb 26, 2010·Clinical Reviews in Allergy & Immunology·Sara E Walker
Mar 31, 2010·Clinical Reviews in Allergy & Immunology·Melissa Cunningham, Gary Gilkeson
Sep 10, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Divaker ChoubeyHongzhu Liu
Dec 14, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Divaker Choubey, Kamal D Moudgil
Jun 13, 2009·Carcinogenesis·Alicia G ClevelandKaren A Gould
Aug 31, 2010·Journal of Molecular Cell Biology·Hui ShenDivaker Choubey
Jan 23, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael J Ryan
Aug 27, 2014·Nature Reviews. Rheumatology·Grant C Hughes, Divaker Choubey
Sep 13, 2014·International Journal of Molecular Sciences·Anselm Mak, Sen Hee Tay
Apr 29, 2015·The Journal of Clinical Investigation·Kira RubtsovaAnatoly V Rubtsov
Sep 3, 2016·Archivum Immunologiae Et Therapiae Experimentalis·Juan Pablo Mackern-ObertiAlexis M Kalergis
Sep 10, 2014·Clinical Therapeutics·Emily L Gilbert, Michael J Ryan
Mar 18, 2016·Therapeutic Advances in Cardiovascular Disease·Erin B Taylor, Michael J Ryan
Dec 15, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chelsea CorradettiRoberto Caricchio
Apr 13, 2018·The Tohoku Journal of Experimental Medicine·Xing-Jie BaoLi-Na Zhang
Feb 5, 2019·British Journal of Pharmacology·Erin B TaylorMichael J Ryan
May 28, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Victoria L WolfMichael J Ryan
Apr 5, 2020·The FEBS Journal·William J OlsonNatascha Hermann-Kleiter
Oct 18, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Emily L Gilbert, Michael J Ryan
Nov 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ravichandran PanchanathanDivaker Choubey

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Clinical Immunology : the Official Journal of the Clinical Immunology Society
John L SvensonGary S Gilkeson
Clinical Immunology : the Official Journal of the Clinical Immunology Society
Jing Li, R W McMurray
Clinical Immunology : the Official Journal of the Clinical Immunology Society
Feng FengJerrie Gavalchin
The Journal of Immunology : Official Journal of the American Association of Immunologists
Ravichandran PanchanathanDivaker Choubey
© 2021 Meta ULC. All rights reserved