Estrogen receptor alpha gene polymorphisms and bone mineral density in healthy children and young adults

Calcified Tissue International
A M BootAndré G Uitterlinden

Abstract

The accretion of peak bone mass is largely under genetic control, and one of the potential candidate genes is the estrogen receptor alpha (ERalpha) gene. The association of ERalpha gene polymorphisms with bone mineral density (BMD) was investigated in a group of 147 healthy caucasian children, adolescents, and young adults (57 boys and 90 girls) in a cross-sectional and longitudinal study. The mean age was 11.3 years (4.3-19.9 years) at baseline and 15.6 years (7.6-25.3 years) at follow-up. Lumbar spine, total body BMD, and body composition were measured by dual energy X-ray absorptiometry and expressed as age- and sex-adjusted standard deviation scores (SDS). We analyzed two restriction fragment length polymorphisms, Pvull and Xbal, and haplotypes thereof. Subjects homozygous for haplotype 1 (px) (33% of the population) had 0.4 SD (standard deviation) lower lumbar spine BMD (P = 0.02) and bone mineral apparent density (BMAD) (P = 0.04) than those heterozygous or noncarriers for haplotype 1 (px) at baseline. Analysis of the follow-up data gave similar results. The association was stronger for the prepubertal than for the postpubertal subjects. Vertebral width SDS, total body BMD SDS, height SDS, body mass index SDS, lean body m...Continue Reading

Citations

Jan 31, 2012·Genetic Testing and Molecular Biomarkers·GuoJun WeiDaMing Dong
Jul 16, 2008·Current Opinion in Pediatrics·Beth A Kaminski, Mark R Palmert
May 20, 2008·Annals of Human Genetics·D Karasik, S L Ferrari
Apr 24, 2009·Reproductive Biology and Endocrinology : RB&E·Francesco MassartMaria Luisa Brandi
May 15, 2012·Pharmacological Reports : PR·Andrzej PawlikAndrzej Bohatyrewicz
Dec 26, 2006·The Journal of Pediatrics·David A StevensonDavid H Viskochil
Nov 10, 2005·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Brad T Tinkle, Richard J Wenstrup
Nov 13, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mattias LorentzonClaes Ohlsson
Apr 19, 2005·Obesity Research·Louis PérusseClaude Bouchard
Dec 18, 2004·American Journal of Physical Anthropology·Osbjorn M Pearson, Daniel E Lieberman
Jun 7, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Marco MediciAndré G Uitterlinden
Nov 30, 2005·Journal of Internal Medicine·C ValeroJ A Riancho
Sep 26, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yong-Jun LiuHong-Wen Deng
Nov 26, 2008·Best Practice & Research. Clinical Endocrinology & Metabolism·Serge Ferrari
Dec 16, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Bouchra EdderkaouiSubburaman Mohan
Jul 19, 2011·Scandinavian Journal of Rheumatology·V DziedziejkoA Pawlik
May 23, 2012·Molecular and Cellular Endocrinology·Chunyan He, Joanne M Murabito
Jun 20, 2017·Clinical Nursing Research·María Correa-RodríguezBlanca Rueda-Medina
Nov 16, 2006·The Journal of Clinical Endocrinology and Metabolism·J H TobiasM A Brown
Jul 26, 2016·Experimental and Therapeutic Medicine·Nataša Karas-KuželičkiIrena Mlinarič-Raščan
Dec 24, 2008·Current Opinion in Endocrinology, Diabetes, and Obesity·Zofia Kz GajdosMark R Palmert
Apr 5, 2007·The Journal of Clinical Endocrinology and Metabolism·J H TobiasM A Brown
Mar 17, 2007·Food and Nutrition Bulletin·Martine A Thomis, Bradford Towne
Jan 12, 2010·Journal of Endocrinological Investigation·B Kulik-RechbergerT Rechberger
Oct 28, 2019·Human Heredity·Nima Montazeri-NajafabadyZahra Mirzai

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