Abstract
Multinucleate cell angiohistiocytoma (MCAH) is a putative reactive skin lesion, which has been reported mostly in adult female patients, and hormones have been recently suggested as a factor influencing its development. To test this hypothesis, monoclonal anti-estrogen receptor (ER) a, anti-progesterone receptor (PR), anti-Factor XIIIa, and polyclonal anti-vascular endothelial growth factor (VEGF) antibodies were applied by immunohistochemistry on a series of 21 MCAHs and, compared to 10 cases of dermatofibroma (DF) and 5 cases of chronic dermatitis presenting multinucleate cells. On normal skin surrounding the lesions and in cases of DF and chronic dermatitis, ERa was expressed in few undifferentiated and differentiated sebocytes, in few cells of anagen follicles and perifollicular mesenchymal cells, and in scattered dermal fibrocytes. In MCAHs, ERa was strongly expressed in interstitial spindle cells, spindle cells surrounding the characteristic vascular component of the lesion, and rare multinucleate cells. PR expression was restricted to sparse spindle cells and few sebocytes, whereas Factor XIIIa stained spindle cells in the dermis of normal and inflamed skin and in both MCAH and DF, and VEGF staining resulted completely n...Continue Reading
References
Aug 1, 1992·The American Journal of Dermatopathology·G AnnessiA Giannetti
May 1, 1990·The British Journal of Dermatology·W E JonesN P Smith
Nov 1, 1989·The Journal of Clinical Investigation·D T ConnollyJ Feder
Aug 1, 1995·The British Journal of Dermatology·D KoperaH Kerl
Aug 1, 1996·Journal of the American Academy of Dermatology·S N ChangW I Yang
Jun 10, 2000·Journal of Cutaneous Pathology·U SassT Simonart
Aug 5, 2000·Maturitas·M P Brincat
Jan 4, 2001·Journal of Dermatological Science·M Detmar
Jan 22, 2002·The American Journal of Dermatopathology·T MentzelH Hügel
May 25, 2002·Journal of Cutaneous Pathology·Lluís PuigAgustín Alomar
Jul 14, 2004·The American Journal of Dermatopathology·Ning LiGiovanni Tallini
Jul 12, 2005·Endocrine Journal·Yoshiyuki KariyaHironobu Sasano
Aug 2, 2005·Journal of Dermatological Science·Ying SongMasaaki Ito
Apr 28, 2006·Journal of Cutaneous Pathology·Reena Sachdev, Uma Sundram
Dec 13, 2006·Archives of Dermatological Research·Hyeon Gyeong YooKwang Hyun Cho
Jun 29, 2007·The British Journal of Dermatology·H J KimT Y Yoon
Mar 6, 2008·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Susan StevensonM Julie Thornton
Dec 2, 2008·Clinical and Experimental Dermatology·Y B RawalS Y Rawal
May 15, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Beatriz Fernández-JorgeEduardo Fonseca
Citations
Oct 15, 2013·Journal of Cutaneous Pathology·Bhavana N Doshi-ChouguleAlmut Böer-Auer
Dec 20, 2014·Clinical and Experimental Dermatology·J N ChuM M Pol-Rodriguez
Dec 27, 2016·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Luca RoncatiTeresa Pusiol
Aug 21, 2014·The American Journal of Dermatopathology·John W Frew
Mar 17, 2015·Journal of Cutaneous Medicine and Surgery·Jennifer A E DoaneSylvia Pasternak
Sep 27, 2018·Journal of Cutaneous Pathology·Elise GrgurichNektarios Lountzis
Dec 1, 2018·Journal of Cutaneous Pathology·Joong-Heon SuhUn-Ha Lee
Aug 18, 2018·Indian Journal of Dermatology, Venereology and Leprology·Adane AyeleAsok Biswas
Mar 31, 2019·Journal of Cutaneous Pathology·Simon F RoyJennifer M McNiff
Jan 29, 2019·The American Journal of Dermatopathology·Shilpa MehtaWarren Piette
Nov 5, 2016·Journal of Cutaneous Pathology·Ming WangSiyuan Chen
Sep 1, 2015·The American Journal of Dermatopathology·Michael WilkBernhard Zelger
Jun 7, 2018·Indian Journal of Dermatology, Venereology and Leprology·Kulsupa NimmannityaSuthinee Rutnin
Apr 27, 2021·The American Journal of Dermatopathology·Casey L RossJason B Lee