Estrogen receptor alpha overexpression in multinucleate cell angiohistiocytoma: new insights into the pathogenesis of a reactive process

The American Journal of Dermatopathology
Anna Maria CesinaroAntonio Maiorana

Abstract

Multinucleate cell angiohistiocytoma (MCAH) is a putative reactive skin lesion, which has been reported mostly in adult female patients, and hormones have been recently suggested as a factor influencing its development. To test this hypothesis, monoclonal anti-estrogen receptor (ER) a, anti-progesterone receptor (PR), anti-Factor XIIIa, and polyclonal anti-vascular endothelial growth factor (VEGF) antibodies were applied by immunohistochemistry on a series of 21 MCAHs and, compared to 10 cases of dermatofibroma (DF) and 5 cases of chronic dermatitis presenting multinucleate cells. On normal skin surrounding the lesions and in cases of DF and chronic dermatitis, ERa was expressed in few undifferentiated and differentiated sebocytes, in few cells of anagen follicles and perifollicular mesenchymal cells, and in scattered dermal fibrocytes. In MCAHs, ERa was strongly expressed in interstitial spindle cells, spindle cells surrounding the characteristic vascular component of the lesion, and rare multinucleate cells. PR expression was restricted to sparse spindle cells and few sebocytes, whereas Factor XIIIa stained spindle cells in the dermis of normal and inflamed skin and in both MCAH and DF, and VEGF staining resulted completely n...Continue Reading

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Citations

Oct 15, 2013·Journal of Cutaneous Pathology·Bhavana N Doshi-ChouguleAlmut Böer-Auer
Dec 20, 2014·Clinical and Experimental Dermatology·J N ChuM M Pol-Rodriguez
Dec 27, 2016·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Luca RoncatiTeresa Pusiol
Mar 17, 2015·Journal of Cutaneous Medicine and Surgery·Jennifer A E DoaneSylvia Pasternak
Sep 27, 2018·Journal of Cutaneous Pathology·Elise GrgurichNektarios Lountzis
Aug 18, 2018·Indian Journal of Dermatology, Venereology and Leprology·Adane AyeleAsok Biswas
Mar 31, 2019·Journal of Cutaneous Pathology·Simon F RoyJennifer M McNiff
Jan 29, 2019·The American Journal of Dermatopathology·Shilpa MehtaWarren Piette
Nov 5, 2016·Journal of Cutaneous Pathology·Ming WangSiyuan Chen
Sep 1, 2015·The American Journal of Dermatopathology·Michael WilkBernhard Zelger
Jun 7, 2018·Indian Journal of Dermatology, Venereology and Leprology·Kulsupa NimmannityaSuthinee Rutnin
Apr 27, 2021·The American Journal of Dermatopathology·Casey L RossJason B Lee

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