Estrogen receptor analyses in breast cancer: comparison of monoclonal immunohistochemical and biochemical methods.

European Journal of Cancer & Clinical Oncology
G SøndergaardS M Paulsen

Abstract

The estrogen receptor content in 100 female breast carcinomas was determined using the biochemical dextran-coated charcoal (DCC) method and the monoclonal estrogen receptor immunocytochemical assay (ER-ICA). Great care was taken to make procedures optimal in order to minimize preanalytical errors. A statistically highly significant correlation was found between the results of the two methods, which were qualitatively in accordance in 91 cases, while nine gave a negative ER-ICA but a weak positive DCC result. The quantitative correlations were also statistically significant but varied considerably in individual cases. Under optimal conditions, ER-ICA provides results similar to the DCC method, but it is still uncertain if it can stand alone in routine diagnosis.

References

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Citations

May 9, 2003·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Masafumi Kurosumi
Oct 1, 1990·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·K Glavind, A Grove
Sep 1, 1996·Pathology, Research and Practice·M FeeP A Dervan
Feb 18, 2004·The Breast : Official Journal of the European Society of Mastology·A CavaliereA Sidoni
Jun 16, 2016·Molecular and Cellular Endocrinology·Alexandre NaccacheMireille Castanet
Aug 17, 2010·Cancer Cell·Chunhua LuAnil K Sood
Mar 15, 2015·Acta Radiologica·Isadora Pontes CavalcanteMaria Candida Barisson Villares Fragoso

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