Estrogen receptor β controls proliferation of enteric glia and differentiation of neurons in the myenteric plexus after damage

Proceedings of the National Academy of Sciences of the United States of America
F D'ErricoJ-Å Gustafsson

Abstract

Injury to the enteric nervous system (ENS) can cause several gastrointestinal (GI) disorders including achalasia, irritable bowel syndrome, and gastroparesis. Recently, a subpopulation of enteric glial cells with neuronal stem/progenitor properties (ENSCs) has been identified in the adult ENS. ENSCs have the ability of reconstituting the enteric neuronal pool after damage of the myenteric plexus. Since the estrogen receptor β (ERβ) is expressed in enteric glial cells and neurons, we investigated whether a selective ERβ agonist, LY3201, can influence neuronal and glial cell differentiation. Myenteric ganglia from the murine muscularis externa were isolated and cultured in either glial cell medium or neuronal medium. In glial cell medium, the number of glial progenitor cells (Sox10+) was increased by fourfold in the presence of LY3201. In the neuronal medium supplemented with an antimitotic agent to block glial cell proliferation, LY3201 elicited a 2.7-fold increase in the number of neurons (neurofilament+ or HuC/D+). In addition, the effect of LY3201 was evaluated in vivo in two murine models of enteric neuronal damage and loss, namely, high-fat diet and topical application of the cationic detergent benzalkonium chloride (BAC) o...Continue Reading

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Citations

Apr 6, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·David GrundmannKarl-Herbert Schäfer
Nov 30, 2019·Journal of Neurochemistry·Osamu ImamuraKunio Takishima
Jun 16, 2019·Environmental Science and Pollution Research International·Yuanyuan WeiXiuhui Zhong
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Oct 2, 2021·Proceedings of the National Academy of Sciences of the United States of America·Mohammad M AhmadzaiBrian D Gulbransen

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