Abstract
Injury to the enteric nervous system (ENS) can cause several gastrointestinal (GI) disorders including achalasia, irritable bowel syndrome, and gastroparesis. Recently, a subpopulation of enteric glial cells with neuronal stem/progenitor properties (ENSCs) has been identified in the adult ENS. ENSCs have the ability of reconstituting the enteric neuronal pool after damage of the myenteric plexus. Since the estrogen receptor β (ERβ) is expressed in enteric glial cells and neurons, we investigated whether a selective ERβ agonist, LY3201, can influence neuronal and glial cell differentiation. Myenteric ganglia from the murine muscularis externa were isolated and cultured in either glial cell medium or neuronal medium. In glial cell medium, the number of glial progenitor cells (Sox10+) was increased by fourfold in the presence of LY3201. In the neuronal medium supplemented with an antimitotic agent to block glial cell proliferation, LY3201 elicited a 2.7-fold increase in the number of neurons (neurofilament+ or HuC/D+). In addition, the effect of LY3201 was evaluated in vivo in two murine models of enteric neuronal damage and loss, namely, high-fat diet and topical application of the cationic detergent benzalkonium chloride (BAC) o...Continue Reading
References
Jan 13, 1998·Nature Genetics·E M Southard-SmithW J Pavan
Apr 15, 2003·Neuron·Jaesang KimDavid J Anderson
Jun 10, 2003·The Journal of Comparative Neurology·Menachem HananiMaria-Simonetta Faussone-Pellegrini
May 6, 2004·Brain Research·Liqin ZhaoRoberta Diaz Brinton
May 13, 2004·Histochemistry and Cell Biology·Naoko KawanoShigeru Kohno
Jun 29, 2005·The Journal of Comparative Neurology·Christie D FowlerZuoxin Wang
Dec 22, 2006·The Journal of Comparative Neurology·Shotaro SuzukiPhyllis M Wise
Sep 7, 2007·Brain Research·Liqin Zhao, Roberta Diaz Brinton
Aug 26, 2011·The Journal of Clinical Investigation·Catia LaranjeiraVassilis Pachnis
Oct 4, 2011·PloS One·Evangelos Delivopoulos, Alan F Murray
Dec 23, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Gabrio BassottiCorrado R Asteria
Jun 6, 2012·Molecular Psychiatry·H SuzukiJ-Å Gustafsson
Feb 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Wan-fu WuJan-Åke Gustafsson
Jun 28, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rory D SpenceRhonda R Voskuhl
Dec 7, 2013·PloS One·Ulrikke VossEva Ekblad
Mar 15, 2014·Cell Cycle·Rachael A McCloyAndrew Burgess
Oct 22, 2014·Digestive Diseases and Sciences·Evandro José BeraldiNilza Cristina Buttow
Feb 24, 2015·Glia·Juliana de Mattos Coelho-AguiarVivaldo Moura-Neto
Mar 6, 2015·Inflammatory Bowel Diseases·Jaime Belkind-GersonAllan M Goldstein
Aug 26, 2015·Best Practice & Research. Clinical Endocrinology & Metabolism·Min JiaJan-Åke Gustafsson
Apr 10, 2016·Developmental Biology·Allan M GoldsteinRoberto De Giorgio
Apr 20, 2017·Proceedings of the National Academy of Sciences of the United States of America·Subhash KulkarniPankaj J Pasricha
Apr 26, 2017·Proceedings of the National Academy of Sciences of the United States of America·Wan-Fu WuJan-Åke Gustafsson
Jun 2, 2017·Scientific Reports·Jaime Belkind-GersonAllan M Goldstein
Sep 16, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·Simon Verheijden, Guy E Boeckxstaens
Citations
Apr 6, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·David GrundmannKarl-Herbert Schäfer
Nov 30, 2019·Journal of Neurochemistry·Osamu ImamuraKunio Takishima
Nov 2, 2019·Scientific Reports·Li WangWan-Fu Wu
Jun 16, 2019·Environmental Science and Pollution Research International·Yuanyuan WeiXiuhui Zhong
Dec 21, 2019·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Kristen A McLaurinCharles F Mactutus
Nov 5, 2019·Frontiers in Pharmacology·Wei ZhouZhigang Liu
Mar 12, 2019·Canadian Journal of Gastroenterology & Hepatology·Sérgio Britto GarciaVinicius Kannen
Apr 6, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·David GrundmannKarl-Herbert Schäfer
Jul 19, 2020·Journal of Pediatric Surgery·Alexis Pierre ArnaudGaelle Boudry
Mar 19, 2021·Nature Reviews. Gastroenterology & Hepatology·Luisa Seguella, Brian D Gulbransen
Oct 2, 2021·Proceedings of the National Academy of Sciences of the United States of America·Mohammad M AhmadzaiBrian D Gulbransen