PMID: 3220085Dec 1, 1988Paper

Estrogen receptor distribution in the peripheral, intermediate and central regions of breast cancers

European Journal of Cancer & Clinical Oncology
J P van NettenC Fletcher


The central, intermediate and peripheral regions of 25 breast tumors were analyzed for estrogen receptors (ER) using a combined biochemical (BC)/immunohistochemical (IHC) micromethod. To optimize the regional comparison, the percentage carcinoma per sample (PCS) was evaluated and incorporated into the quantification of the ER. Correction of the measured ER for the PCS eliminated differences in receptor levels between the central and peripheral regions but not the intermediate region. Although the corrected BC-ER level in this region was found to be about 20% higher, the IHC method did not detect such a difference. Determination of the ER status at the actual growth front of a tumor, rather than in the intermediate region where ER levels appear to be highest, may be of greater clinical relevance. Intra-regional ER heterogeneity appears, however, to be particularly pronounced in this area of a tumor.


Jan 1, 1987·Journal of Steroid Biochemistry·G FabrisI Nenci
Jan 1, 1984·Breast Cancer Research and Treatment·C B LazierK Lonergan
Mar 1, 1982·Journal of Steroid Biochemistry·B MoncharmontP Cuatrecasas
Jan 1, 1980·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C SilfverswärdB Nordenskjöld


Jan 1, 1993·Breast Cancer Research and Treatment·R ClarkeN Brünner
Oct 6, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Nobukazu TakahashiE Edmund Kim
Apr 9, 2009·Breast Cancer Research and Treatment·Evangelia-Ourania FourkalaMartin Widschwendter
Jun 1, 2001·The Journal of Steroid Biochemistry and Molecular Biology·R ClarkeF Leonessa
Apr 25, 2000·Nuclear Medicine and Biology·L VaragnoloE K Pauwels
Aug 1, 1990·Journal of Clinical Pathology·J P van NettenC Fletcher
Apr 4, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Rakesh Kumar
Aug 1, 1990·Journal of Clinical Pathology·B DelahuntJ N Nacey
Nov 29, 2013·Journal of Labelled Compounds & Radiopharmaceuticals·Hee Seup KilDae Yoon Chi
May 1, 1991·The British Journal of Surgery·Z Rayter

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