Estrogen receptor-immunoreactive neurons are present in the female rat lumbosacral spinal cord

Journal of Neuroscience Research
S J Williams, R E Papka

Abstract

Presence of an estrogen receptor is crucial for cells to respond to estrogen; thus, estrogen-responsive neurons should be identifiable by immunohistochemically staining for the estrogen receptor (ER). Even though spinal neurons are involved in sexual behaviors and innervation of genital organs, little information is available about ER-containing neurons in the spinal cord. Consequently, we have undertaken a study of ER-containing neurons in the female rat lumbosacral cord, an area involved in reproductive functions and predicted to contain estrogen-responsive neurons. In addition, since parasympathetic preganglionic neurons in the lumbosacral cord produce nitric oxide (NO), we also sought to determine if ER-immunoreactive (-IR) neurons contain the enzymes for NO production. Finally, we compared the distribution of ER-IR neurons to the presence of uterine cervix-related neurons. Uterine cervix-related neurons were identified by expression of FOS-immunoreactivity after vaginocervical mechanostimulation (VCS). The lumbosacral spinal cords were removed from intact, ovariectomized, and VCS-treated rats and sections stained by immunohistochemistry. ER-IR was present in the nuclei of neurons located predominately in the dorsal one-hal...Continue Reading

References

Dec 1, 1978·Science·W D WillisD R Kenshalo
Jan 1, 1992·Hormone Research·B S McEwen
Dec 8, 1990·The Journal of Comparative Neurology·M KawataniW C de Groat
Aug 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·B S McEwenC Woolley
Jan 15, 1990·The Journal of Comparative Neurology·R BursteinG J Giesler
Jan 1, 1988·Journal of Neurophysiology·K J BerkleyY Sato
Nov 22, 1988·Neuroscience Letters·G PelletierM V Govindan
Apr 7, 1987·Brain Research·L C PetersB R Komisaruk
Jun 22, 1986·The Journal of Comparative Neurology·K E McKenna, I Nadelhaft
Sep 15, 1973·The Journal of Comparative Neurology·D Pfaff, M Keiner
Jun 1, 1994·Trends in Neurosciences·G J GieslerR J Dado
Aug 22, 1993·The Journal of Comparative Neurology·Y Delville, J D Blaustein
Feb 1, 1946·The Anatomical Record·M ABERCROMBIE

❮ Previous
Next ❯

Citations

May 23, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Analía RicheriM Mónica Brauer
Oct 11, 2011·Pain Research and Treatment·Victor Chaban
Nov 22, 2002·Journal of Neuroscience Research·R E PapkaM Storey-Workley
Oct 10, 2003·Neuroreport·Richard N RansonAlan H D Watson
Jun 16, 2009·European Journal of Pain : EJP·Asa Amandusson, Anders Blomqvist
May 24, 2011·The Journal of Urology·Chen-Li Cheng, William C de Groat
Nov 22, 2013·American Journal of Physiology. Renal Physiology·Chen-Li Cheng, William C de Groat
Jul 6, 2000·The Journal of Comparative Neurology·H EvrardJ Balthazart
Jul 27, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kent SteningAnders Blomqvist
Aug 18, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Henry C Evrard
Sep 9, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·E Hösli, L Hösli
Aug 13, 2003·The Journal of Urology·Annette SchröderKarl-Erik Andersson
Jul 19, 2000·Journal of Neuroscience Research·K A BurkeK P Nephew
Jun 22, 1999·Hormones and Behavior·J ManzoB D Sachs
May 7, 2009·Frontiers in Neuroendocrinology·Paul Micevych, Reymundo Dominguez

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.