Estrogen receptor positive breast cancers and their association with environmental factors.

International Journal of Health Geographics
Sophie St-HilaireDeWayne Derryberry

Abstract

Epidemiological studies to assess risk factors for breast cancer often do not differentiate between different types of breast cancers. We applied a general linear model to determine whether data from the Surveillance, Epidemiology, and End Results Program on annual county level age-adjusted incidence rates of breast cancer with and without estrogen receptors (ER+ and ER-) were associated with environmental pollutants. Our final model explained approximately 38% of the variation in the rate of ER+ breast cancer. In contrast, we were only able to explain 14% of the variation in the rate of ER- breast cancer with the same set of environmental variables. Only ER+ breast cancers were positively associated with the EPA's estimated risk of cancer based on toxic air emissions and the proportion of agricultural land in a county. Meteorological variables, including short wave radiation, temperature, precipitation, and water vapor pressure, were also significantly associated with the rate of ER+ breast cancer, after controlling for age, race, premature mortality from heart disease, and unemployment rate. Our findings were consistent with what we expected, given the fact that many of the commonly used pesticides and air pollutants included...Continue Reading

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Citations

Dec 28, 2012·Journal of Mammary Gland Biology and Neoplasia·Nagendra YadavaChul Kim
Feb 4, 2014·PloS One·Prathap Kumar S Mahalingaiah, Kamaleshwar P Singh
Mar 7, 2014·Journal of Zhejiang University. Science. B·Jie DingXiao-gang Guo
Jan 26, 2016·Epidemiology·Nicole M NiehoffDale P Sandler
May 24, 2017·Carcinogenesis·Antonio AgudoCarlos A González
Jan 1, 2014·International Journal of Circumpolar Health·Adrianne K HolmesCarol H Rubin
Jan 21, 2018·Cancer Research·Katarzyna A LudwikDeborah A Lannigan
Dec 3, 2014·International Journal of Circumpolar Health·Adrianne K HolmesCarol H Rubin

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Methods Mentioned

BETA
hormone replacement therapies
hormone replacement therapy

Software Mentioned

ArcGIS
excel
WONDER

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