Estrogen receptor-positive breast carcinomas in younger women are different from those of older women: a pathological and immunohistochemical study

The Breast : Official Journal of the European Society of Mastology
Livia M BacchiFilomena M Carvalho

Abstract

The higher frequency of triple-negative and HER-2-positive tumors detected in younger patients has been suggested as an explanation for the more aggressive tumor types observed in this age group. However, estrogen receptor (ER)-positive tumors are the most frequent subtype of breast carcinomas identified, even in younger patients. In this retrospective study, the morphological and immunohistochemical profiles of ER-positive breast carcinomas from women 35 yrs and younger that were diagnosed between 1997 and 2007 were evaluated. From these cases, 213 were selected based on the availability of pathology reports and paraffin blocks. For comparison, 117 consecutive cases of breast carcinomas diagnosed in patients >60 yrs from 2006 were included. Paraffin-embedded tumors were stained for expression of ER, progesterone receptor (PR), human epidermal growth factor receptor 2 (HER-2), Ki-67 antigen, epidermal growth factor receptor (EGFR), cytokeratin 5/6, p53, vimentin, CD117, and p63 using tissue microarrays. ER-positive carcinomas were diagnosed in 120 (56.1%) samples of the younger patient group and in 92 (78.6%) samples of the older patient group. Of these ER-positive carcinomas, 48 (40%) from the younger patient group presented t...Continue Reading

References

Sep 13, 2001·Proceedings of the National Academy of Sciences of the United States of America·T SørlieA L Børresen-Dale
Aug 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Torsten O NielsenCharles M Perou
Dec 2, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Therese Sørlie
Jul 22, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sunil R LakhaniUNKNOWN Breast Cancer Linkage Consortium
Nov 1, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sandy AzoulayAnne Vincent-Salomon
Jun 8, 2006·JAMA : the Journal of the American Medical Association·Lisa A CareyRobert C Millikan
Apr 3, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sherene LoiChristos Sotiriou
Apr 5, 2008·JAMA : the Journal of the American Medical Association·Chaitanya R AcharyaAnil Potti
Jun 3, 2008·The Oncologist·Jeffrey S RossGabriel N Hortobágyi
Jul 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carey K AndersKimberly L Blackwell
Aug 7, 2008·Breast Cancer Research : BCR·Rulla M TamimiLaura C Collins
Aug 30, 2008·Pathology Oncology Research : POR·Rita Bori, Gábor Cserni
Dec 17, 2008·Archives of Gynecology and Obstetrics·Mar MuñozJosé Schneider
Feb 11, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Judith HughCharles Vogel
Apr 22, 2009·Virchows Archiv : an International Journal of Pathology·M GraeserUNKNOWN German Consortium for Hereditary Breast and Ovarian Cancer

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Citations

Nov 15, 2011·Breast Cancer Research and Treatment·L C CollinsA H Partridge
Sep 3, 2011·European Journal of Cancer Care·D J AndersonJ Porter-Steele
May 23, 2015·The Breast : Official Journal of the European Society of Mastology·Rafael de Deus MouraCarlos E Bacchi
Aug 2, 2016·The Breast : Official Journal of the European Society of Mastology·Laura SabianiEric Lambaudie
Nov 8, 2017·AJR. American Journal of Roentgenology·Cindy S LeeBethany L Niell

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