Estrogen-Receptor, Progesterone-Receptor and HER2 Status Determination in Invasive Breast Cancer. Concordance between Immuno-Histochemistry and MapQuant™ Microarray Based Assay

PloS One
D MouttetF Reyal

Abstract

Hormone receptor status and HER2 status are of critical interest in determining the prognosis of breast cancer patients. Their status is routinely assessed by immunohistochemistry (IHC). However, it is subject to intra-laboratory and inter-laboratory variability. The aim of our study was to compare the estrogen receptor, progesterone receptor and HER2 status as determined by the MapQuant™ test to the routine immuno-histochemical tests in early stage invasive breast cancer in a large comprehensive cancer center. We retrospectively studied 163 invasive early-stage breast carcinoma with standard IHC status. The genomic status was determined using the MapQuant™ test providing the genomic grade index. We found only 4 tumours out of 161 (2.5%) with discrepant IHC and genomic results concerning ER status. The concordance rate between the two methods was 97.5% and the Cohen's Kappa coefficient was 0.89. Comparison between the MapQuant™ PR status and the PR IHC status gave more discrepancies. The concordance rate between the two methods was 91.4% and the Cohen's Kappa coefficient was 0.74. The HER2 MapQuant™ test was classified as « undetermined » in 2 out of 163 cases (1.2%). One HER2 IHC-negative tumour was found positive with a high ...Continue Reading

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Citations

Oct 19, 2017·Briefings in Bioinformatics·Emmanuel S Adabor, George K Acquaah-Mensah
Oct 11, 2019·Clinical Pathology·Ana Amélia de SouzaAndresa Borges Soares
Aug 10, 2017·Oncology Letters·Fuqian YangNana Zhao
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Nov 14, 2018·Bioinformatics·Xiaoqian WangHeng Huang
Dec 20, 2020·Clinical Genetics·Agata SzymiczekMohammad R Akbari
Oct 29, 2021·Pharmacology Research & Perspectives·Esther P BonittoKerry B Goralski

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Software Mentioned

R
Mammaprint
Affymetrix
MapQuant Dx
MapQuant

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